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dpe (A9CH28) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed8
Chains with at least one site assessed as druggable using the strict criteria8
Chains with at least one site assessed as druggable using the relaxed criteria8


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2HK1_C D-psicose 3-epimerase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 74.7 30 Yes Yes
2 empty 1.97 78 11.4 No No
3 empty 2.32 75.8 14.4 No No
4 empty 2.12 69.9 16.3 No No
5 empty 2.17 73.1 12.5 No No
6 empty 1.9 60 18.6 No No
7 empty 2.27 64.9 10.6 No No
8 empty 1.62 69.7 10.7 No No
9 empty 2.56 68.7 7.9 No No
10 empty 1.85 60.7 10.3 No No
2HK0_B D-psicose 3-epimerase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 73.3 37.7 Yes Yes
2 empty 2.29 70.2 15.6 No No
3 empty 2.02 76.5 29.2 No No
4 empty 2.21 62.4 21.1 No No
5 empty 1.63 67.3 13 No No
6 empty 1.97 70.9 11.2 No No
7 empty 2.24 61.9 11.4 No No
8 empty 2.45 69.3 9.2 No No
9 empty 1.92 58 10.4 No No
10 empty 2.45 69.9 8.9 No No
2HK0_C D-psicose 3-epimerase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.58 73.5 37.2 Yes Yes
2 empty 2.24 77.9 19.3 No No
3 empty 2.27 74.5 14.4 No No
4 empty 2.02 69.7 11.5 No No
5 empty 2.28 66.1 9.8 No No
6 empty 2.02 69.3 10.1 No No
7 empty 1.84 61.7 11 No No
8 empty 2.57 72.3 7.7 No No
9 empty 2.51 67.6 7.1 No No
10 empty 1.95 78.7 11 No No
2HK0_D D-psicose 3-epimerase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 82.4 21.9 Yes Yes
2 empty 2.08 72.5 37.8 No No
3 empty 2.25 68.7 14.1 No No
4 empty 2.23 61.3 24.7 No No
5 empty 2.11 74.4 15.4 No No
6 empty 2.08 66 12.1 No No
7 empty 2.29 63.1 10.6 No No
8 empty 2.47 66.4 8.4 No No
9 empty 2.02 75.3 8.8 No No
10 empty 1.82 63.2 10.5 No No
2HK1_D D-psicose 3-epimerase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.41 76.4 34.2 Yes Yes
2 empty 2.04 70 36.6 No No
3 empty 2.29 71.7 13.7 No No
4 empty 1.85 58.9 11.8 No No
5 empty 1.92 68.6 11.6 No No
6 empty 2.3 59.7 10.1 No No
7 empty 1.5 82.6 7.1 No No
8 empty 2.4 65.9 9 No No
9 empty 2.47 62.6 11.2 No No
10 empty 1.98 58.9 11.3 No No
2HK1_A D-psicose 3-epimerase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 74 38 Yes Yes
2 empty 2.22 76.3 11.6 No No
3 empty 2.24 70.8 14 No No
4 empty 2.11 70.3 11.4 No No
5 empty 2.11 63.5 10.6 No No
6 empty 2 63.2 12.3 No No
7 empty 1.59 69.5 8.9 No No
8 empty 2.5 74.1 9.4 No No
9 empty 1.85 67.4 10.6 No No
10 empty 1.9 67.8 9.1 No No
2HK1_B D-psicose 3-epimerase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.56 72.8 39.3 Yes Yes
2 empty 2.31 70 15.4 No No
3 empty 1.95 75.8 14.4 No No
4 empty 2.09 69.4 11.1 No No
5 empty 1.76 67.6 13 No No
6 empty 2.26 61.7 11.3 No No
7 empty 1.82 60.3 11.8 No No
8 empty 2.4 69 9.1 No No
9 empty 1.79 69.8 8.9 No No
10 empty 1.91 63.4 9.9 No No
2HK0_A D-psicose 3-epimerase Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 73 36.3 Yes Yes
2 empty 2.07 73.8 15.1 No No
3 empty 2.26 69.5 14.2 No No
4 empty 2.18 69.8 9.2 No No
5 empty 1.61 66.9 16.4 No No
6 empty 2.26 62.3 10.9 No No
7 empty 1.74 67.6 10.3 No No
8 empty 2.5 69.5 8.3 No No
9 empty 2.5 64.1 9.4 No No
10 empty 1.82 60.3 10.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed6
Domains assessed as druggable using the strict criteria4
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2HK0_C (4184516) D-psicose 3-epimerase TIM beta/alpha-barrel, (2r)-phospho-3-sulfolactate synthase ComA, (2r)-phospho-3-sulfolactate synthase ComA (Homo Multimer) 2Å Yes Yes
2HK0_D (4184516) D-psicose 3-epimerase TIM beta/alpha-barrel, (2r)-phospho-3-sulfolactate synthase ComA, (2r)-phospho-3-sulfolactate synthase ComA (Homo Multimer) 2Å Yes Yes
2HK0_B (4184516) D-psicose 3-epimerase TIM beta/alpha-barrel, (2r)-phospho-3-sulfolactate synthase ComA, (2r)-phospho-3-sulfolactate synthase ComA (Homo Multimer) 2Å Yes Yes
2HK0_A (3110178) D-psicose 3-epimerase PFAM, PFAM, PFAM AP_endonuc_2 2Å Yes Yes
2HK0_A (3110179) D-psicose 3-epimerase beta-Trefoil, STI-like, Kunitz (STI) inhibitors 2Å Yes No
2HK0_A (4184516) D-psicose 3-epimerase TIM beta/alpha-barrel, (2r)-phospho-3-sulfolactate synthase ComA, (2r)-phospho-3-sulfolactate synthase ComA (Homo Multimer) 2Å Yes Yes
2HK1_A (4176169) D-psicose 3-epimerase TIM beta/alpha-barrel, (2r)-phospho-3-sulfolactate synthase ComA, (2r)-phospho-3-sulfolactate synthase ComA (Homo Multimer) 2.3Å Yes Yes
2HK1_C (4176169) D-psicose 3-epimerase TIM beta/alpha-barrel, (2r)-phospho-3-sulfolactate synthase ComA, (2r)-phospho-3-sulfolactate synthase ComA (Homo Multimer) 2.3Å Yes Yes
2HK1_B (4176169) D-psicose 3-epimerase TIM beta/alpha-barrel, (2r)-phospho-3-sulfolactate synthase ComA, (2r)-phospho-3-sulfolactate synthase ComA (Homo Multimer) 2.3Å Yes Yes
2HK1_A (3110182) D-psicose 3-epimerase beta-Trefoil, STI-like, Kunitz (STI) inhibitors 2.3Å Yes No
2HK1_A (3110181) D-psicose 3-epimerase PFAM, PFAM, PFAM AP_endonuc_2 2.3Å Yes Yes
2HK1_D (4176169) D-psicose 3-epimerase TIM beta/alpha-barrel, (2r)-phospho-3-sulfolactate synthase ComA, (2r)-phospho-3-sulfolactate synthase ComA (Homo Multimer) 2.3Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score