Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

KCNU1 (A8MYU2) - Overview - Molecular Target Synopsis

Protein


KCNU1, Potassium channel subfamily U member 1
UniProt A8MYU2

Also Known as KCNU1_HUMAN, KCNU1, KCNMA3, KCNMC1, SLO3

Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. Homotetramer; which constitutes the calcium-activated potassium channel. May interact with LRRC52; this interaction may change channel gating properties, such as shifting gating to more negative potentials at a given pH.

4HPF
STRUCTURE OF THE HUMAN SLO3 GATING RING
RCSB/PDB
Inspect Structure
See all 3D Structures for KCNU1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: KCNU1 is active in the following subcellular-locations: cell membrane.
GO terms: KCNU1 is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project KCNU1 has gain in 8 cell-lines, loss in 8 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, ACHN, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1395, NCI-H209, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For KCNU1 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


KCNU1 has been screened with compounds ( bioactivities). (see details)