Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL13 (A8INQ0) - Overview - Molecular Target Synopsis

Protein


ARL13, ADP-ribosylation factor-like protein 13B
UniProt A8INQ0

Also Known as ARL13_CHLRE, ARL13

Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B (By similarity). Monomer.

5DI3
CRYSTAL STRUCTURE OF ARL13B IN COMPLEX WITH ARL3 OF CHLAMYDOMONAS REINHARDTII
RCSB/PDB
Inspect Structure
See all 3D Structures for ARL13

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
527A8INQ0-1

Sub-cellular localization


UniProt: ARL13 is active in the following subcellular-locations: cell projection, cilium membrane.
GO terms: ARL13 is active in the following subcellular-locations: ciliary membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL13 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ARL13 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL13 has been screened with compounds ( bioactivities). (see details)