Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

npmA (A8C927) - Overview - Molecular Target Synopsis

Protein


npmA, 16S rRNA (adenine(1408)-N(1))-methyltransferase
Enzyme Classification 2.1.1.180
UniProt A8C927

Also Known as NPMA_ECOLX, npmA

Specifically methylates the N(1) position of adenine 1408 in 16S rRNA. Confers resistance to various aminoglycosides, including kanamycin, neomycin, apramycin, ribostamycin and gentamicin. Methylates only fully assembled 30S subunits.

4OX9
CRYSTAL STRUCTURE OF THE AMINOGLYCOSIDE RESISTANCE METHYLTRANSFERASE NPMA BOUND TO THE 30S RIBOSOMAL SUBUNIT
RCSB/PDB
Inspect Structure
See all 3D Structures for npmA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
219A8C927-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project npmA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For npmA there are:
6 structures (13 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis