Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(A8BQJ3) - Overview - Molecular Target Synopsis

Protein


, Endoribonuclease Dicer-like
Enzyme Classification 3.1.26.-
UniProt A8BQJ3

Also Known as DCL_GIAIC

Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Homodimer.

2QVW
STRUCTURE OF GIARDIA DICER REFINED AGAINST TWINNED DATA
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
754A8BQJ3-1

Sub-cellular localization


GO terms: is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
2 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis