Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

NCBP2L (A6PVI3) - Overview - Molecular Target Synopsis


NCBP2L, Nuclear cap-binding protein subunit 2-like
UniProt A6PVI3

Also Known as NCB2L_HUMAN, NCBP2L

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

GO terms: NCBP2L is active in the following subcellular-locations: nuclear cap binding complex.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project NCBP2L has gain in 0 cell-lines, loss in 31 cell-lines and no signal in 974 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 50% identity similarity to NCBP2L there are:
11 structures (24 chains) solved
6 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis