Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NCBP2L (A6PVI3) - Overview - Molecular Target Synopsis

Protein


NCBP2L, Nuclear cap-binding protein subunit 2-like
UniProt A6PVI3

Also Known as NCB2L_HUMAN, NCBP2L

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
153ENSG00000170935ENST00000509000ENSP00000476955A6PVI3-1
122ENSG00000170935ENST00000372379ENSP00000361454

Sub-cellular localization


GO terms: NCBP2L is active in the following subcellular-locations: nuclear cap binding complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NCBP2L has gain in 0 cell-lines, loss in 31 cell-lines and no signal in 974 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to NCBP2L there are:
11 structures (24 chains) solved
6 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis