Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RIMBP3C (A6NJZ7) - Overview - Molecular Target Synopsis

Protein


RIMBP3C, RIMS-binding protein 3C
UniProt A6NJZ7

Also Known as RIM3C_HUMAN, RIMBP3C

Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Interacts with LRGUK (via guanylate kinase-like domain). Interacts (via C-terminus) with HOOK1 (via coiled-coil region) (By similarity). May interact with FASLG (PubMed:19807924).

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1769ENSG00000183246ENST00000433039ENSP00000390630
1639A6NJZ7-1
1597ENSG00000183246ENST00000331505ENSP00000350885

Sub-cellular localization


UniProt: RIMBP3C is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: RIMBP3C is active in the following subcellular-locations: cytoplasm, cytoskeleton, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RIMBP3C has gain in 9 cell-lines, loss in 1 cell-lines and no signal in 991 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, MOLT_4, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For RIMBP3C there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis