Molecular Target Synopsis
Overview
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Druggability
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DDTL (A6NHG4) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed12
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria6


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4Q3F_B D-dopachrome decarboxylase-like protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 70.8 16.9 Yes Yes
2 empty 2.08 60.4 11 No No
3 empty 1.99 51.6 15.4 No No
4 empty 1.86 66.9 13.3 No No
5 empty 2.17 57 13 No No
6 empty 2.56 61.6 18.1 No No
7 empty 2.14 60.4 8.4 No No
8 empty 1.13 57.4 8.4 No No
9 empty 2.12 51 8.9 No No
10 empty 2.55 76.5 7.1 No No
1DPT_A D-dopachrome decarboxylase-like protein No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.08 66.2 17.2 No No
2 empty 1.92 54.9 13.3 No No
3 empty 2.02 61.9 17.3 No No
4 empty 1.91 58.2 8.8 No No
5 empty 2.5 60.9 18.9 No No
6 empty 2.31 64.3 11.2 No No
7 empty 2.25 54.3 10.9 No No
8 empty 2.01 53.8 8.3 No No
9 empty 2.54 75 7.9 No No
10 empty 1.71 51.7 8.2 No No
4Q3F_C D-dopachrome decarboxylase-like protein No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.17 67.8 18.3 No No
2 empty 2.18 54 13 No No
3 empty 1.58 55.3 14 No No
4 empty 2.11 57.8 10 No No
5 empty 2.13 61 8 No No
6 empty 2.47 74.9 8.5 No No
7 empty 2.19 53.2 10.1 No No
8 empty 2.45 64 15.1 No No
9 empty 1.92 71.5 6.6 No No
10 empty 2.74 63.5 7.8 No No
1DPT_C D-dopachrome decarboxylase-like protein No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 65.4 17.5 No No
2 empty 2.02 54.5 11.9 No No
3 empty 2.15 55.7 13 No No
4 empty 2.04 68.4 10.2 No No
5 empty 2.43 66.7 8.2 No No
6 empty 2.01 55.4 9.8 No No
7 empty 2.15 58.1 11 No No
8 empty 2.15 58.7 11.7 No No
9 empty 2.5 72.2 9.6 No No
10 empty 2.32 65 9.9 No No
3KAN_A D-dopachrome decarboxylase-like protein No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.28 63 23.2 No No
2 empty 1.97 55.8 13.9 No No
3 empty 2.35 56.5 13.1 No No
4 empty 1.93 62.1 15.5 No No
5 empty 2.15 58.8 10.4 No No
6 empty 2.11 55.9 12 No No
7 empty 2.16 56.1 11.1 No No
8 empty 2.65 66.7 14.1 No No
9 empty 2.74 65.1 9.1 No No
10 empty 2.61 73.3 8.3 No No
6C5F_A D-dopachrome decarboxylase-like protein Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 64.1 27.1 Yes No
2 empty 1.92 61.8 11 No No
3 empty 1.82 65.9 10 No No
4 empty 2.15 56.4 13.7 No No
5 empty 1.97 56.9 8.1 No No
6 empty 1.76 61 8.1 No No
7 empty 1.13 59.3 9.1 No No
8 empty 2.16 66 6.5 No No
9 empty 1.93 56.9 9.6 No No
10 empty 2.22 49.7 8 No No
6C5F_B D-dopachrome decarboxylase-like protein Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.36 64.3 26.3 Yes No
2 empty 1.8 55.9 15.9 No No
3 empty 1.89 65.6 14.3 No No
4 empty 2.28 61.2 11 No No
5 empty 2.32 57.4 10.2 No No
6 empty 1.88 56.9 11.5 No No
7 empty 2.5 67.4 8 No No
8 empty 3.01 85.6 7.3 Yes No
9 empty 2.26 60.6 7.1 No No
10 empty 1.69 64.7 6.1 No No
6C5F_C D-dopachrome decarboxylase-like protein No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 61.3 18.1 No No
2 empty 2.37 64.7 14.3 No No
3 empty 1.95 52.5 13.8 No No
4 empty 1.79 69.5 7.8 No No
5 empty 2.18 58.4 9.8 No No
6 empty 2.63 64.1 17.2 No No
7 empty 2.23 54.5 9.4 No No
8 empty 1.47 64.7 8 No No
9 empty 2.29 57.9 7.5 No No
10 empty 3.07 58.2 8.3 No No
3KAN_B D-dopachrome decarboxylase-like protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.15 67.5 17.4 Yes Yes
2 empty 1.83 61.1 13 No No
3 empty 1.95 55.6 15 No No
4 empty 1.97 66.3 15.9 No No
5 empty 2.41 56.5 9.7 No No
6 empty 2.09 60.3 11 No No
7 empty 1.98 58.7 8.6 No No
8 empty 2.18 62.9 8 No No
9 empty 2.69 63.3 13.8 No No
10 empty 1.21 56 8.6 No No
1DPT_B D-dopachrome decarboxylase-like protein No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 71.2 17.3 No No
2 empty 2.36 59.4 13.2 No No
3 empty 1.96 63.4 11.6 No No
4 empty 1.62 54.2 14.3 No No
5 empty 1.97 58.8 10.5 No No
6 empty 2.18 53.1 11.2 No No
7 empty 2.18 60.6 7.6 No No
8 empty 2.6 69.9 8.6 No No
9 empty 2.28 62.1 8.4 No No
10 empty 2.79 60.6 9.1 No No
3KAN_C D-dopachrome decarboxylase-like protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.13 69.6 16.4 Yes Yes
2 empty 1.97 57.7 12.5 No No
3 empty 1.59 55 16.9 No No
4 empty 2.14 55.9 10.3 No No
5 empty 1.96 67.1 12.1 No No
6 empty 2.3 63.2 7.2 No No
7 empty 1.95 56 8.6 No No
8 empty 2.18 52.1 8.9 No No
9 empty 2.66 64.4 8 No No
10 empty 2.58 72.6 8.8 No No
4Q3F_A D-dopachrome decarboxylase-like protein Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.07 68.3 17.1 Yes Yes
2 empty 1.9 56.9 14.2 No No
3 empty 2.06 54.5 12.7 No No
4 empty 1.95 57.4 11 No No
5 empty 2.13 57.8 12.3 No No
6 empty 1.85 67.6 8.2 No No
7 empty 2.04 59.4 9.6 No No
8 empty 2.59 68.3 9.5 No No
9 empty 2 68.2 6.2 No No
10 empty 2.56 66.8 7.3 No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score