Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DDTL (A6NHG4) - Overview - Molecular Target Synopsis

Protein


DDTL, D-dopachrome decarboxylase-like protein
Enzyme Classification 4.1.1.-
UniProt A6NHG4

Also Known as DDTL_HUMAN, DDTL

May have lyase activity.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
134ENSG00000099974ENST00000215770ENSP00000215770A6NHG4-1

Sub-cellular localization


UniProt: DDTL is active in the following subcellular-locations: cytoplasm.
GO terms: DDTL is active in the following subcellular-locations: cytoplasm, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DDTL has gain in 5 cell-lines, loss in 3 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: EVSA-T, DMS 454, KYSE-520

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, MCF-7

(see details)

3D Structures


For DDTL there are:
4 structures (12 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


DDTL has been screened with compounds ( bioactivities). (see details)