Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL5C (A6NH57) - Overview - Molecular Target Synopsis

Protein


ARL5C, Putative ADP-ribosylation factor-like protein 5C
UniProt A6NH57

Also Known as ARL5C_HUMAN, ARL5C, ARL12

Binds and exchanges GTP and GDP.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
179ENSG00000141748ENST00000444555, ENST00000269586ENSP00000387615, ENSP00000269586A6NH57-1
99ENSG00000141748ENST00000578912ENSP00000466347

Sub-cellular localization


GO terms: ARL5C is active in the following subcellular-locations: cytoplasm, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL5C has gain in 13 cell-lines, loss in 3 cell-lines and no signal in 988 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: ML-2, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to ARL5C there are:
5 structures (9 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL5C has been screened with compounds ( bioactivities). (see details)