Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ARL5C (A6NH57) - Overview - Molecular Target Synopsis


ARL5C, Putative ADP-ribosylation factor-like protein 5C
UniProt A6NH57

Also Known as ARL5C_HUMAN, ARL5C, ARL12

Binds and exchanges GTP and GDP.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
179ENSG00000141748ENST00000444555, ENST00000269586ENSP00000387615, ENSP00000269586A6NH57-1

Sub-cellular localization

GO terms: ARL5C is active in the following subcellular-locations: cytoplasm, trans-Golgi network.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ARL5C has gain in 13 cell-lines, loss in 3 cell-lines and no signal in 988 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: ML-2, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 50% identity similarity to ARL5C there are:
5 structures (9 chains) solved
5 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ARL5C has been screened with compounds ( bioactivities). (see details)