Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FABP12 (A6NFH5) - Overview - Molecular Target Synopsis

Protein


FABP12, Fatty acid-binding protein 12
UniProt A6NFH5

Also Known as FBP12_HUMAN, FABP12

May play a role in lipid transport.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
140ENSG00000197416ENST00000360464ENSP00000353650A6NFH5-1
91ENSG00000197416ENST00000519696ENSP00000427973

Sub-cellular localization


GO terms: FABP12 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FABP12 has gain in 18 cell-lines, loss in 2 cell-lines and no signal in 985 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to FABP12 there are:
104 structures (146 chains) solved
84 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

FABP12 is solved in complex with the approved drug(s):

IBP/DEXIBUPROFEN (3P6H_A),
TAR/TARTARIC ACID (4LKT_B, 4LKT_C, 4LKT_D),
FLU/FLUORESCEIN (6AYL_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FABP12 has been screened with compounds ( bioactivities). (see details)