Molecular Target Synopsis
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CNOT1 (A5YKK6) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed27
Chains with at least one site assessed as druggable using the strict criteria7
Chains with at least one site assessed as druggable using the relaxed criteria25


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5ONA_D CCR4-NOT transcription complex subunit 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 67.3 30.6 Yes Yes
2 empty 2.11 68.2 25.8 No No
3 empty 2.37 61.5 29.4 No No
4 empty 2.15 63.8 20.8 No No
5 empty 2.33 66.1 22.6 No No
6 bound 2.1 63.3 15.4 No No
7 empty 2.58 62.5 15.1 No No
8 empty 2.23 59.7 13.3 No No
9 empty 2.01 57.9 11.3 No No
10 empty 2.2 65 15.5 No No
4CRW_A CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 67 25.8 Yes No
2 empty 2.08 67.5 25.1 No No
3 empty 2.16 71.7 17.3 No No
4 empty 2.04 59.4 20.2 No No
5 empty 2.17 62 14.8 No No
6 bound 1.79 67.3 19.2 No No
7 empty 2.03 63.5 15 No No
8 empty 2.15 62.8 17.7 No No
9 empty 2.21 69 13.4 No No
10 empty 2.32 67.4 10 No No
4J8S_A CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.6 68.6 25 Yes No
2 empty 2.16 68 22.7 No No
3 empty 2.02 67.5 12.7 No No
4 empty 2.43 60 19.5 No No
5 empty 2.03 55.9 12 No No
6 empty 1.84 67.7 12.7 No No
7 empty 1.83 64.8 12.2 No No
8 empty 2.58 62.1 10.7 No No
9 empty 1.99 66.2 9.9 No No
10 empty 2.25 61.3 12.4 No No
4CT4_A CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 68.3 26.7 Yes No
2 empty 2.14 64.2 19.1 No No
3 empty 2.23 65 28.1 No No
4 empty 2.11 60.4 23 No No
5 empty 2.26 64.3 19.3 No No
6 empty 2.47 68.5 17.7 No No
7 empty 2.17 73.1 13 No No
8 empty 1.77 65.7 15.9 No No
9 empty 1.91 71.8 13.6 No No
10 empty 1.79 85.3 11.3 Yes No
4GMJ_E CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.07 64.8 40.5 Yes No
2 empty 1.91 68.5 23.5 No No
3 empty 2.17 68.8 24.2 No No
4 empty 2.05 61.5 19.9 No No
5 empty 2 66.2 14.6 No No
6 empty 1.66 64.9 13.6 No No
7 empty 2.42 62.4 14.5 No No
8 empty 2.13 70.3 15.7 No No
9 empty 1.71 63.8 10.7 No No
10 empty 2.32 71.7 10.3 No No
4CT4_C CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 64.6 36.9 Yes No
2 empty 2 61.4 24.6 No No
3 empty 2.1 69.8 26.9 No No
4 empty 2.08 61.7 21.1 No No
5 empty 2.11 61.8 18.7 No No
6 empty 2.35 67 18.6 No No
7 empty 1.67 69.5 11.9 No No
8 empty 1.68 65.6 15.3 No No
9 empty 1.97 69.5 13.1 No No
10 empty 1.86 67 14.8 No No
5ONA_A CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 54.6 26.2 Yes No
2 empty 1.74 60.5 26 No No
3 empty 2 60 19.8 No No
4 empty 1.7 52.3 18.3 No No
5 empty 1.68 67.8 11.6 No No
6 empty 1.96 56.7 12.8 No No
7 empty 2.1 54 12.5 No No
8 empty 2.1 54 14.2 No No
9 empty 2.32 63.9 11.9 No No
10 empty 1.55 56.2 13.2 No No
4CT6_A CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 63.5 31.7 Yes No
2 empty 1.85 69.1 30.4 No No
3 empty 2.03 61.7 21.5 No No
4 empty 2.48 66.9 15.5 No No
5 empty 1.77 47.2 14.3 No No
6 empty 1.86 63.1 16.3 No No
7 empty 2.23 62.1 16.1 No No
8 empty 2.1 61.4 12.1 No No
9 empty 1.81 69.6 15.1 No No
10 empty 2.3 67.2 13.9 No No
4GML_A CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 66.1 24.9 Yes No
2 empty 2.08 68.8 23.3 No No
3 empty 1.83 66.1 28.5 No No
4 empty 2.36 60.9 24.2 No No
5 empty 1.98 61.3 17.5 No No
6 empty 1.72 70.1 18.4 No No
7 empty 2.15 54.6 10 No No
8 empty 2.24 63.2 9.1 No No
9 empty 1.92 64.3 12.2 No No
10 empty 2.43 65.5 9.4 No No
5FU6_D CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 64.8 45.3 Yes No
2 empty 2.15 64.7 40.2 No No
3 empty 2.04 61.6 40.1 No No
4 empty 1.84 70.4 30 No No
5 empty 1.59 64.4 24.5 No No
6 empty 1.86 62 29.7 No No
7 empty 2.13 61.1 21.9 No No
8 empty 1.95 66.7 14.6 No No
9 empty 1.74 68 14 No No
10 empty 2.35 65.2 19.3 No No
4CT7_A CCR4-NOT transcription complex subunit 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 66.3 31.5 Yes Yes
2 empty 1.94 65.2 32 No No
3 empty 2 63.8 17.8 No No
4 empty 2.17 61.4 14.1 No No
5 empty 1.85 62.2 15.6 No No
6 empty 1.74 52 14.7 No No
7 empty 1.99 68.9 13.8 No No
8 empty 2.21 64 16.1 No No
9 empty 2.29 63.5 14.9 No No
10 empty 2.26 61.7 15 No No
4GMJ_C CCR4-NOT transcription complex subunit 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 69.9 22.9 No No
2 empty 2.07 66.8 21.4 No No
3 empty 2.02 68.4 17.6 No No
4 empty 2 58.6 19.3 No No
5 empty 2.17 69.7 17.2 No No
6 empty 2.18 64.9 16.6 No No
7 empty 2 65.6 14.8 No No
8 empty 1.82 62.8 14.8 No No
9 empty 2.56 63.6 14.1 No No
10 empty 2.54 72.3 10.3 No No
4GML_F CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 66.8 32.7 Yes No
2 empty 2.52 67.5 23.6 No No
3 empty 1.89 67.6 25.6 No No
4 empty 2.04 67.8 21.8 No No
5 empty 2 61.5 14.2 No No
6 empty 2.29 65.5 12.7 No No
7 empty 2.56 74 9.4 No No
8 empty 2.61 68.5 11.9 No No
9 empty 2.41 60.9 13.2 No No
10 empty 2.49 67.6 13.5 No No
5FU7_E CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 64.4 47 Yes No
2 empty 2.22 61.6 43.9 No No
3 empty 2.15 64.8 32.4 No No
4 empty 1.79 65.1 29.6 No No
5 empty 1.88 61.4 22.4 No No
6 empty 2.19 66.5 25.8 No No
7 empty 2.1 71.1 18.9 No No
8 empty 1.74 67.9 25.2 No No
9 empty 1.92 72.3 18.4 No No
10 empty 2.15 59.8 26 No No
4CQO_A CCR4-NOT transcription complex subunit 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.66 66.3 38.7 Yes Yes
2 empty 2.06 68.8 29.7 No No
3 empty 2.01 67 23.9 No No
4 empty 2.57 63.8 30.4 No No
5 empty 2.25 64.6 19 No No
6 empty 1.77 66 24.1 No No
7 empty 2.15 67.5 22 No No
8 empty 1.73 64.8 21.3 No No
9 empty 2.02 63.8 24.3 No No
10 empty 1.9 59.7 22.6 No No
4GMJ_A CCR4-NOT transcription complex subunit 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 66.4 27.5 Yes Yes
2 empty 2.17 66.6 20.3 No No
3 empty 2 69.1 18.1 No No
4 empty 2.2 66.9 14.5 No No
5 empty 2 59 15.1 No No
6 empty 2.12 62.7 13 No No
7 empty 1.54 69.1 12.2 No No
8 empty 1.68 65.3 8.6 No No
9 empty 2.31 63.7 15.3 No No
10 empty 2.26 67.1 10.3 No No
4C0D_A CCR4-NOT transcription complex subunit 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 66.8 38.8 Yes Yes
2 empty 1.74 68.6 37.1 No No
3 empty 2.02 61 39.7 No No
4 empty 1.76 64.8 32.6 No No
5 empty 1.81 66.2 25.9 No No
6 empty 2.38 66.7 19.7 No No
7 empty 2.26 65 26.2 No No
8 empty 1.79 65.3 18.1 No No
9 empty 2.51 63.4 16.9 No No
10 empty 2.41 64.8 23.5 No No
4GML_E CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 65.4 35.8 Yes No
2 empty 2.1 70.2 23.3 No No
3 empty 2.09 72.8 17.7 No No
4 empty 1.85 63.2 14.1 No No
5 empty 2.21 64.8 13.6 No No
6 empty 1.67 68.1 12.7 No No
7 empty 2.34 68.3 12.5 No No
8 empty 2.58 63 11.1 No No
9 empty 2.45 71.6 7.9 No No
10 empty 2.39 92.1 0 Yes No
4GML_B CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 65.3 30.9 Yes No
2 empty 2.11 67.6 23.8 No No
3 empty 2.31 70 22.3 No No
4 empty 1.77 63.4 25.1 No No
5 empty 2.14 64.6 13.4 No No
6 empty 2.52 60 12.5 No No
7 empty 2.02 69.9 13.8 No No
8 empty 2.44 75.3 9.4 No No
9 empty 2.54 68.3 9.9 No No
10 empty 2.18 70 7.9 No No
5ANR_A CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.12 70.8 25.2 Yes No
2 empty 2.12 58.6 20.5 No No
3 empty 1.95 67.9 15.8 No No
4 empty 1.96 65.9 23.3 No No
5 empty 1.66 67.6 11.1 No No
6 empty 1.96 70.7 13.5 No No
7 empty 2.27 62.3 15.3 No No
8 empty 1.7 63.6 15.2 No No
9 empty 1.82 56.4 14.6 No No
10 empty 2.37 62.7 10.6 No No
4CRU_A CCR4-NOT transcription complex subunit 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 62.8 23.6 No No
2 empty 2.12 64.5 31.1 No No
3 bound 2.21 62.2 22.2 No No
4 empty 2.04 55.2 18.7 No No
5 empty 2.05 66.4 17 No No
6 empty 2.31 65.7 20 No No
7 empty 1.87 60.4 15.8 No No
8 empty 2.15 58.7 10.5 No No
9 empty 2.34 58.1 13.4 No No
10 empty 2.16 58.5 12.1 No No
4GML_D CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.18 66 34.6 Yes No
2 empty 2.08 71 20.6 No No
3 empty 1.85 68.7 23.4 No No
4 empty 2.04 77.4 10.1 No No
5 empty 2.28 61.3 19.1 No No
6 empty 2.03 60.8 21.1 No No
7 empty 1.8 67.9 16.7 No No
8 empty 1.68 60.7 13.4 No No
9 empty 2.77 66.9 9.6 No No
10 empty 2.28 63.3 11.2 No No
5FU6_A CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 63.8 52.8 Yes No
2 empty 2.02 65.4 46.8 No No
3 empty 2.11 69.5 26.3 No No
4 empty 2.1 60 28.2 No No
5 empty 1.79 66.6 26.6 No No
6 empty 1.67 64.3 25.2 No No
7 empty 2.14 62.5 21.9 No No
8 empty 2.02 60.2 23.8 No No
9 empty 2.32 62.5 23.8 No No
10 empty 2.21 61.7 16.8 No No
5FU7_A CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 65.9 50 Yes No
2 empty 1.7 65.2 31.9 No No
3 empty 2.19 67.3 30.5 No No
4 empty 2.09 66.3 19.3 No No
5 empty 2.36 63.2 31.7 No No
6 empty 2.11 60.6 32.3 No No
7 empty 1.78 63.1 25.2 No No
8 empty 1.92 61.1 19.7 No No
9 empty 2.19 66.9 26.3 No No
10 empty 2.24 64.4 20 No No
4CRV_A CCR4-NOT transcription complex subunit 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 67.4 30.2 Yes Yes
2 empty 2.1 61.2 21.2 No No
3 empty 2.06 66.1 16.4 No No
4 empty 1.99 63.5 17.5 No No
5 empty 2.31 56.2 21 No No
6 empty 2.43 63.2 16.6 No No
7 empty 2.1 65.5 15.1 No No
8 empty 1.6 71.6 8.3 No No
9 empty 2.18 54 13.6 No No
10 empty 2.13 57 12.7 No No
4GML_C CCR4-NOT transcription complex subunit 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 66.8 35.1 Yes Yes
2 empty 2.33 68.3 18.8 No No
3 empty 1.94 72.2 13.7 No No
4 empty 2.02 61.8 18.5 No No
5 empty 1.63 67.6 13.8 No No
6 empty 1.66 69.1 13.5 No No
7 empty 2.36 63.1 11.4 No No
8 empty 2.27 67.9 8.6 No No
9 empty 2.38 74.2 9.6 No No
10 empty 2.83 57.1 13.5 No No
4CQO_C CCR4-NOT transcription complex subunit 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 64.3 38 Yes No
2 empty 1.85 65 33.3 No No
3 empty 2.19 64.4 39.3 No No
4 empty 2.34 63.3 19.1 No No
5 empty 2.24 61.3 27.1 No No
6 empty 1.82 64.7 20.9 No No
7 empty 2.17 70.6 22.1 No No
8 empty 2.49 61.6 15 No No
9 empty 1.82 68.4 15.2 No No
10 empty 2.07 58.6 25.4 No No
Ligand-based Druggability Score: 0.5
Ligand-based Druggability Score Percentile: 85%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


CNOT1 is involved in 16 interactions in the network.


Druggability
Overall Druggability Percentile: 84.68
Druggability for Cancer Therapeutics: 83.48
Druggability for Other Therapeutics: 53.15
Cancer-Associated
Cancer-associated percentile : 87.76
Network Articulation Point
Is CNOT1 critical for communication in the network?


Detailed Graph Legend:Help