CNOT1 (A5YKK6) - Overview - Molecular Target Synopsis
CNOT1, CCR4-NOT transcription complex subunit 1
Also Known as CNOT1_HUMAN, CNOT1, CDC39, KIAA1007, NOT1
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity. Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex, interacts directly with CNOT6, CNOT6L, CNOT7 or CNOT8. Interacts in a ligand-dependent fashion with ESR1 and RXRA. Interacts with NANOS2, TOB1 and ZFP36. Interacts with TNRC6A, TNRC6B or TNRC6C; the interactions are direct.
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UniProt: CNOT1 is active in the following subcellular-locations: cytoplasm, nucleus, p-body.
GO terms: CNOT1 is active in the following subcellular-locations: CCR4-NOT complex, CCR4-NOT core complex, cytosol, extracellular space, membrane, nucleus, P-body, peroxisomal membrane.