Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

(A4JS72) - Overview - Molecular Target Synopsis

Protein


, DNA-binding protein Bv3F
UniProt A4JS72

Also Known as BV3F_BURVG

A DNA-binding protein implicated in transcriptional repression and chromosome organization and compaction. Binds in the minor groove of AT-rich DNA (PubMed:21673140). Binds nucleation sites in AT-rich DNA and bridges them, forming higher-order nucleoprotein complexes and condensing the chromosome. As many horizontally transferred genes are AT-rich, it plays a central role in silencing foreign genes. Homodimer that oligomerizes on DNA into higher-order complexes that form bridges between disparate regions of DNA compacting it.

2L92
SOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF H-NS LIKE PROTEIN BV3F
RCSB/PDB
Inspect Structure
See all 3D Structures for

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
112A4JS72-1

Sub-cellular localization


UniProt: is active in the following subcellular-locations: cytoplasm, nucleoid.
GO terms: is active in the following subcellular-locations: cytoplasm, nucleoid.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis