Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB19 (A4D1S5) - Overview - Molecular Target Synopsis

Protein


RAB19, Ras-related protein Rab-19
UniProt A4D1S5

Also Known as RAB19_HUMAN, RAB19, RAB19B

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB19 is active in the following subcellular-locations: cell membrane.
GO terms: RAB19 is active in the following subcellular-locations: endoplasmic reticulum membrane, extracellular exosome, Golgi membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB19 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVKATE, PE01, UMC-11

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to RAB19 there are:
10 structures (18 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB19 has been screened with compounds ( bioactivities). (see details)