Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ODAM (A1E959) - Overview - Molecular Target Synopsis

Protein


ODAM, Odontogenic ameloblast-associated protein
UniProt A1E959

Also Known as ODAM_HUMAN, ODAM, APIN

Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. Interacts (via C-terminus) with ARHGEF5.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ODAM is active in the following subcellular-locations: cytoplasm, nucleus, secreted.
GO terms: ODAM is active in the following subcellular-locations: cell periphery, cytoplasm, extracellular region, extracellular space, nucleus, supramolecular fiber.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ODAM has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, EKVX

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CL-11, HCC1187, SNU-620

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)