ODAM (A1E959) - Overview - Molecular Target Synopsis
ODAM, Odontogenic ameloblast-associated protein
Also Known as ODAM_HUMAN, ODAM, APIN
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. Interacts (via C-terminus) with ARHGEF5.
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UniProt: ODAM is active in the following subcellular-locations: cytoplasm, nucleus, secreted.
GO terms: ODAM is active in the following subcellular-locations: cell periphery, cytoplasm, extracellular region, extracellular space, nucleus, supramolecular fiber.