Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TLDC2 (A0PJX2) - Overview - Molecular Target Synopsis

Protein


TLDC2, TLD domain-containing protein 2
UniProt A0PJX2

Also Known as TLDC2_HUMAN, TLDC2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
215ENSG00000101342ENST00000602922, ENST00000217320ENSP00000473323, ENSP00000217320A0PJX2-1
27ENSG00000101342ENST00000436941ENSP00000394804

Gene Copy Number Variation


In COSMIC - Cell Lines Project TLDC2 has gain in 7 cell-lines, loss in 1 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 205, COLO 206F, SNU-719

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to TLDC2 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis