Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTT4 (A0A1W2PR19) - Overview - Molecular Target Synopsis

Protein


GSTT4, Glutathione S-transferase theta-4
Enzyme Classification 2.5.1.18
UniProt A0A1W2PR19

Also Known as GSTT4_HUMAN, GSTT4, GSTTP1

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Homodimer.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: GSTT4 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTT4 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTT4 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

3D Structures


At greater than 35% identity similarity to GSTT4 there are:
8 structures (22 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis