Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

esiB (A0A0H2VDN9) - Overview - Molecular Target Synopsis

Protein


esiB, Secretory immunoglobulin A-binding protein EsiB
UniProt A0A0H2VDN9

Also Known as ESIB_ECOL6, esiB

Upon host (human neutrophil) infection interferes with productive FCAR signaling, inhibiting secreted IgA (SIgA) effector functions and probably avoiding neutrophil activation. Inhibits the SIgA-mediated oxidative burst by neutrophils, decreases generation of ROS (reactive oxygen species) by neutrophils and reduces chemotaxis by neutrophils, all of which are SIgA effector functions used to stimulate the immune response. Does not block SIgA-binding to its receptor (FCAR) on neutrophils, but it decreases SIgA-stimulated phosphorylation of cytoplasmic proteins, including phospholipase C-gamma and MAP kinases, all actions that may be advantageous to the pathogen. Interacts with human secreted IgA (SIgA) at least via resides 244-260.

4BWR
CRYSTAL STRUCTURE OF C5321: A PROTECTIVE ANTIGEN PRESENT IN UROPATHOGENIC ESCHERICHIA COLI STRAINS DISPLAYING AN SLR FOLD
RCSB/PDB
Inspect Structure
See all 3D Structures for esiB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: esiB is active in the following subcellular-locations: cell surface.
GO terms: esiB is active in the following subcellular-locations: cell surface.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project esiB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For esiB there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis