Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

SIK1B (A0A0B4J2F2) - Overview - Molecular Target Synopsis


SIK1B, Probable serine/threonine-protein kinase SIK1B
Enzyme Classification
UniProt A0A0B4J2F2

Also Known as SIK1B_HUMAN, SIK1B

Probable serine/threonine-protein kinase.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

GO terms: SIK1B is active in the following subcellular-locations: cytoplasm, nucleotide-activated protein kinase complex, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project SIK1B has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

3D Structures

At greater than 50% identity similarity to SIK1B there are:
19 structures (47 chains) solved
4 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

SIK1B has been screened with compounds ( bioactivities). (see details)