Objective Assessment of Cancer Genes for Drug Discovery - Supplementary Information S2 (479 Genes)


Objective Assessment of Cancer Genes for Drug Discovery
Mishal N. Patel, Mark D. Halling-Brown, Joseph E. Tym, Paul Workman and Bissan Al-Lazikani
doi: 10.1038/nrd3913

For up to date annotation please click the link below.
Click here to open this list of genes in the Cancer Protein Annotation Tool

Please note the following changes have been observed in UniProt since publication, the table below has been updated accordingly:
KIAA1618 (Q9HCF4) -> RNF213 (Q63HN8)



Gene Name Link to Target Synopsis
VGFR2 P35968
EGFR P00533
PPARG P37231
LCK P06239
ERBB2 P04626
PGFRB P09619
ABL1 P00519
MET P08581
BRAF P15056
KIT P10721
ITK Q08881
FGFR1 P11362
PGFRA P16234
FLT3 P36888
JAK2 O60674
RAF1 P04049
TOP1 P11387
RARA P10276
FGFR2 P21802
ALK Q9UM73
JAK1 P23458
ALDH2 P05091
DNM3A Q9Y6K1
JAK3 P52333
SMO Q99835
ABL2 P42684
FGFR3 P22607
RASN P01111
RASK P01116
PK3CA P42336
AKT1 P31749
CDK4 P11802
AKT2 P31751
PIM1 P11309
HS90B P08238
HS90A P07900
KSYK P43405
BCL2 P10415
CHK2 O96017
NTRK1 P04629
RET P07949
NFKB2 Q00653
RASH P01112
P53 P04637
P85A P27986
CDK6 Q00534
PUR9 P31939
STK11 Q15831
MP2K4 P45985
RB P06400
BRD4 O60885
CTNB1 P35222
IL2 P60568
KAP0 P10644
GUAA P49915
FUMH P07954
EP300 Q09472
BRCA1 P38398
TSHR P16473
KLK2 P20151
PTN11 Q06124
DNM2 P50570
BMR1A P36894
FHIT P49789
CCNE1 P24864
CCND1 P24385
TPOR P40238
CCND2 P30279
CCND3 P30281
MDM2 Q00987
JUN P05412
BCR P11274
BIRC3 Q13489
ERCC5 P28715
MDM4 O15151
NTRK3 Q16288
HG2A P04233
TTL Q8NG68
ROS1 P08922
ATM Q13315
ATF1 P18846
PCSK7 Q16549
RUNX1 Q01196
NPM P06748
CBP Q92793
PERF P14222
REL Q04864
NR4A3 Q92570
WIF1 Q9Y5W5
TNAP3 P21580
TIF1A O15164
TFR1 P02786
SMCA4 P51532
SMAD4 Q13485
PMS2 P54278
PD1L1 Q9NZQ7
PB1 Q86U86
PALB2 Q86YC2
PA1B2 P68402
NU214 P35658
NSD3 Q9BZ95
NF1 P21359
MTG8 Q06455
CBFA2T3 O75081
MSH6 P52701
MSH2 P43246
MOES P26038
MLH1 P40692
NF2 P35240
KDM6A O15550
KAT6A Q92794
IF4A2 Q14240
IDH1 O75874
GNAS2 P63092
GNAS1 Q5JWF2
GNAQ P50148
GNA11 P29992
FBXW7 Q969H0
DDX6 P26196
DDB2 Q92466
CYLD Q9NQC7
COE1 Q9UH73
CLH1 Q00610
CDN2C P42773
CBLB Q13191
CBL P22681
CANT1 Q8WVQ1
BRD3 Q15059
ATRX P46100
ARNT P27540
PPP2R1A P30153
YWHAE P62258
CBLC Q9ULV8
NCOA1 Q15788
KIF5B P33176
WRN Q14191
SOX2 P48431
ROA2 P22626
PAX7 P23759
PAX3 P23760
KDM5C P41229
KDM5A P29375
IDHP P48735
FNBP1 Q96RU3
FLI1 Q01543
ERG P11308
ELK4 P28324
DICER Q9UPY3
CADH1 P12830
TRI33 Q9UPN9
SH3G1 Q99961
SEPT5 Q99719
PSIP1 O75475
PER1 O15534
OLIG2 Q13516
NSD2 O96028
NSD1 Q96L73
MYH9 P35579
MYH11 P35749
KAT6B Q8WYB5
HIP1 O00291
FOXL2 P58012
FEV Q99581
ETV5 P41161
ETV4 P43268
ETV1 P50549
ELF4 Q99607
CLH2 P53675
CAD11 P55287
BRCA2 P51587
RBTN1 P25800
FSTL3 O95633
NOTC2 Q04721
NOTC1 P46531
WWTR1 Q9GZV5
TMPS2 O15393
CXCR7 P25106
P2RY8 Q86VZ1
IL6RB P40189
LIFR P42702
ZBT16 Q05516
XPO1 O14980
XPF Q92889
XPA P23025
WASP P42768
VHL P40337
U2AF1 Q01081
TNR6 P25445
TNR17 Q02223
TNR14 Q92956
TF7L2 Q9NQB0
TCEA1 P23193
SUFU Q9UMX1
SRSF3 P84103
SETD2 Q9BYW2
SET Q01105
SEPT6 Q14141
SBDS Q9Y3A5
RMI2 Q96E14
RHG26 Q9UNA1
RECQ4 O94761
RBTN2 P25791
PRDM1 O75626
PMS1 P54277
PLSL P13796
PICAL Q13492
PEBB Q13951
PDGFB P01127
PBX1 P40424
PAX8 Q06710
PAX5 Q02548
PATZ1 Q9HBE1
NUP98 P52948
MYD88 Q99836
MYB P10242
MUTYH Q9UIF7
MUC1 P15941
MTCP1 P56278
MSI2H Q96DH6
MLL1 Q03164
MALT1 Q9UDY8
IRF4 Q15306
HXA9 P31269
HNF1A P20823
HIST1H4I P62805
GNDS Q12967
GEPH Q9NQX3
GATA3 P23771
GATA2 P23769
FUBP1 Q96AE4
FOXP1 Q9H334
FOXO4 P98177
FOXO3 O43524
FOXO1 Q12778
FCG2B P31994
FANCE Q9HB96
EWS Q01844
ETV6 P41212
EPS15 P42566
ELL P55199
DHSB P21912
DEK P35659
DDX5 P17844
CHIN P15882
CD79B P40259
CD2A1 P42771
C560 Q99643
BUB1B O60566
BLM P54132
BCL9 O00512
BCL6 P41182
ASPC1 Q9BZE9
ARHGC Q9NZN5
AFAD P55196
TRI27 P14373
TLX3 O43711
TLX1 P31314
SRSF2 Q01130
RBP56 Q92804
RBM15 Q96T37
PRRX1 P54821
PO5F1 Q01860
PHX2B Q99453
PD1L2 Q9BQ51
NKX21 P43699
NDRG1 Q92597
NCOA2 Q15596
MNX1 P50219
MLL2 O14686
LASP1 Q14847
KLF6 Q99612
HXD11 P31277
HXC11 O43248
HXA13 P31271
HXA11 P31270
GATA1 P15976
FUS P35637
DUX4 Q9UBX2
DHSD O14521
DDX10 Q13206
COX6C P09669
CNBP P62633
CIC Q96RK0
CDX2 Q99626
BTG1 P62324
ARI1A O14497
ZN521 Q96K83
ZN384 Q8TF68
ZN331 Q9NQX6
ZMYM2 Q9UBW7
XPC Q01831
WT1 P19544
VTI1A Q96AJ9
UBP6 P35125
U2AFM Q15696
TSC2 P49815
TSC1 Q92574
TRIPB Q15643
TR150 Q9Y2W1
TPR P12270
TPM4 P67936
TPM3 P06753
TFPT P0C1Z6
TFG Q92734
TFEB P19484
TFE3 P19532
TFE2 P15923
TET2 Q6N021
TET1 Q8NFU7
TCL6 P56846
TCL1A P56279
TAL2 Q16559
TAL1 P17542
SYCC P49589
SUZ12 Q15022
STIL Q15468
SSXT Q15532
SSX4 O60224
SSX2 Q16385
SSX1 Q16384
SRGP2 O43295
SPN90 Q9NZQ3
SOCS1 O15524
SNX29 Q8TEQ0
SNF5 Q12824
SFPQ P23246
SF3B1 O75533
SEPT9 Q9UHD8
SDHF2 Q9NX18
S45A3 Q96JT2
RPN1 P04843
RL22 P35268
RHOH Q15669
RBP17 Q9H2T7
RB6I2 Q8IUD2
RABE1 Q15276
RA51B O15315
PTEN P60484
PTC1 Q13635
PRD16 Q9HAZ2
PRCC Q92733
PML P29590
PLAG1 Q6DJT9
PCM1 Q15154
OMD Q99983
OBF1 Q16633
NUT Q86Y26
NUMA1 Q14980
NONO Q15233
NIN Q8N4C6
NFIB O00712
NF2L2 Q16236
NCOA4 Q13772
NBN O60934
NACA Q13765
MYOME Q5VU43
MYCN P04198
MYCL1 P12524
MYC P01106
MN1 Q10571
MLL3 Q8NEZ4
MLF1 P58340
MKL1 Q969V6
MITF O75030
MEN1 O00255
MED12 Q93074
MDS2 Q8NDY4
MDS1 Q13465
MAML2 Q8IZL2
MAFB Q9Y5Q3
MAF O75444
LYL1 P12980
LPP Q93052
LHFP Q9Y693
KTN1 Q86UP2
RNF213 Q63HN8
KDSR Q06136
K1549 Q9HCM3
JAZF1 Q86VZ6
IL7RA P16871
IL21R Q9HBE5
IKZF1 Q13422
HXD13 P35453
HXC13 P31276
HTF4 Q99081
HOOK3 Q86VS8
HMGN2P46 Q86SG4
HMGA2 P52926
HMGA1 P17096
HLF Q16534
HEY1 Q9Y5J3
HERP1 Q15011
GPC3 P51654
GOPC Q9HD26
GOGA5 Q8TBA6
GNAS3 O95467
GDS1 P52306
GAS7 O60861
FR1OP O95684
FLCN Q8NFG4
FIP1 Q6UN15
FCRL4 Q96PJ5
FBX11 Q86XK2
FANCJ Q9BX63
FANCG O15287
FANCF Q9NPI8
FANCC Q00597
FANCA O15360
FACD2 Q9BXW9
FA46C Q5VWP2
FA22B A6NNL0
FA22A Q8IVF1
F123B Q5JTC6
EZH2 Q15910
EXT2 Q93063
EXT1 Q16394
EVI1 Q03112
ERCC3 P19447
ERCC2 P18074
ENL Q03111
EMAL4 Q9HC35
ELN P15502
DDIT3 P35638
DAXX Q9UER7
CYTSB Q5M775
CRTC3 Q6UUV7
CRTC1 Q6UUV9
CRLF2 Q9HC73
CREST O75177
CREB1 P16220
CR3L2 Q70SY1
CR3L1 Q96BA8
CO1A1 P02452
CNTRL Q7Z7A1
CLP1 Q92989
CIP1 Q9NPC3
CHIC2 Q9UKJ5
CHCH7 Q9BUK0
CEBPA P49715
CDK12 Q9NYV4
CDC73 Q6P1J9
CD79A P11912
CD2A2 Q8N726
CCNL1 Q9UK58
CCDC6 Q16204
CASC5 Q8NG31
CAR11 Q9BXL7
C2TA P33076
BCOR Q6W2J9
BCL7A Q4VC05
BCL3 P20749
BCL10 O95999
BC11B Q9C0K0
BC11A Q9H165
BAP1 Q92560
ASXL1 Q8IXJ9
ARID2 Q68CP9
APC P25054
ALEX P84996
AKAP9 Q99996
AFF4 Q9UHB7
AFF3 P51826
AFF1 P51825
AF9 P42568
AF1Q Q13015
AF17 P55198
AF10 P55197
ACSL6 Q9UKU0
ACSL3 O95573
ABI1 Q8IZP0
ECT2L Q008S8
LRIG3 Q6UXM1
CAMTA1 Q9Y6Y1
SLC34A2 O95436
H3F3A P84243
PHF6 Q8IWS0
SDC4 P31431
EZR P15311
C2ORF44 Q9H6R7