Browse Protein Families
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Browse Protein Families with Family Name Starting with S

0 - 1 - 2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z - ALL

Family Level # members # members with tested compounds # members with 3D structures # members with Druggable 3D structures
small GTPase superfamily
superfamily 160 13 83 47
Ser/Thr protein kinase family
family 67 52 31 29
STE Ser/Thr protein kinase family
family 54 51 36 28
short-chain dehydrogenases/reductases (SDR) family
family 54 14 22 21
serpin family
family 38 6 19 16
SNF2/RAD54 helicase family
family 32 1 12 4
sulfotransferase 1 family
family 32 12 17 16
sorting nexin family
family 31 0 14 5
STE20 subfamily
subfamily 29 27 18 15
splicing factor SR family
family 28 0 12 3
S-100 family
family 23 2 18 7
semaphorin family
family 20 0 2 2
Sp1 C2H2-type zinc-finger protein family
family 19 1 3 0
sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
family 19 10 1 1
synaptotagmin family
family 18 0 6 2
sulfatase family
family 17 3 5 3
small leucine-rich proteoglycan (SLRP) family
family 17 0 0 0
syntaxin family
family 16 0 6 0
SIGLEC (sialic acid binding Ig-like lectin) family
family 15 2 3 0
snRNP Sm proteins family
family 15 0 10 0
Sugar transporter (TC 2.A.1.1) family
family 14 6 2 2
SNF1 subfamily
subfamily 14 14 7 7
Septin GTPase family
family 13 0 5 4
sodium:solute symporter (SSF) (TC 2.A.21) family
family 12 5 0 0
SPATA31 family
family 12 0 0 0
SNF7 family
family 12 0 9 1
synaptobrevin family
family 11 0 4 0
SLC26A/SulP transporter (TC 2.A.53) family
family 11 0 0 0
Speedy/Ringo family
family 11 0 0 0
secretoglobin family
family 11 0 0 0
SLC30A subfamily
subfamily 10 0 1 0
S6 kinase subfamily
subfamily 10 9 4 4
sodium channel (TC 1.A.1.10) family
family 10 10 4 2
SRC subfamily
subfamily 10 10 6 5
small heat shock protein (HSP20) family
family 9 1 3 1
SPAN-X family
family 9 0 0 0
SLC12A transporter family
family 9 2 0 0
Sodium/anion cotransporter family
family 9 0 0 0
SSX family
family 9 0 0 0
shisa family
family 8 0 0 0
STXBP/unc-18/SEC1 family
family 8 0 3 3
SMC family
family 8 0 3 2
STrpC subfamily
subfamily 7 3 0 0
sirtuin family
family 7 7 6 6
spectrin family
family 7 0 5 1
SIMIBI class G3E GTPase family
family 7 0 1 1
Schlafen family
family 7 0 0 0
SCC3 family
family 7 0 1 0
sulfotransferase 2 family
family 7 0 0 0
small Tim family
family 6 0 2 0
somatotropin/prolactin family
family 6 0 4 4
sterol desaturase family
family 6 0 0 0
SLC24A subfamily
subfamily 6 0 0 0
SIX/Sine oculis homeobox family
family 6 0 1 1
SLITRK family
family 6 0 1 0
S100-fused protein family
family 6 0 1 0
SEC23/SEC24 family
family 6 0 5 5
SLC35F solute transporter family
family 6 0 0 0
SLC35A subfamily
subfamily 5 0 0 0
SLC13A/DASS transporter (TC 2.A.47) family
family 5 0 0 0
SLRP class II subfamily
subfamily 5 0 0 0
sideroflexin family
family 5 0 0 0
snail C2H2-type zinc-finger protein family
family 5 0 1 1
steroid 5-alpha reductase family
family 5 2 1 0
synaptogyrin family
family 5 0 0 0
syntrophin family
family 5 0 1 0
SKI2 subfamily
subfamily 5 0 1 1
SLC35G solute transporter family
family 5 0 0 0
SPIN/STSY family
family 5 0 3 0
STEAP family
family 5 0 1 0
secreted frizzled-related protein (sFRP) family
family 5 1 0 0
SAPAP family
family 5 0 0 0
SelWTH family
family 5 0 1 0
SCAMP family
family 5 0 0 0
SEC6 family
family 5 0 0 0
SLC35E subfamily
subfamily 5 0 0 0
SLC35B subfamily
subfamily 4 0 0 0
SLC29A/ENT transporter (TC 2.A.57) family
family 4 1 0 0
STKL subfamily
subfamily 4 1 0 0
SUMO subfamily
subfamily 4 0 3 2
Suvar3-9 subfamily
subfamily 4 4 4 3
shroom family
family 4 0 2 0
sprouty family
family 4 0 2 0
stathmin family
family 4 0 0 0
synaptophysin/synaptobrevin family
family 4 0 0 0
syndecan proteoglycan family
family 4 0 2 0
SEC24 subfamily
subfamily 4 0 4 4
SET2 subfamily
subfamily 4 3 4 4
SOWAH family
family 4 0 0 0
SPSB family
family 4 0 3 0
sal C2H2-type zinc-finger protein family
family 4 0 0 0
sarcoglycan beta/delta/gamma/zeta family
family 4 0 0 0
sauvagine/corticotropin-releasing factor/urotensin I family
family 4 0 4 0
serine esterase family
family 4 1 0 0
SCM family
family 4 0 2 1
SH3BGR family
family 4 0 3 0
SKI family
family 4 0 2 1
SLRP class I subfamily
subfamily 4 0 0 0
SLC35D subfamily
subfamily 3 0 0 0
SLC8 subfamily
subfamily 3 1 0 0
SLRP class III subfamily
subfamily 3 0 0 0
SLRP class IV subfamily
subfamily 3 0 0 0
SORCS subfamily
subfamily 3 0 1 0
Secernin subfamily
subfamily 3 0 0 0
Sedlin subfamily
subfamily 3 0 0 0
Sterol o-acyltransferase subfamily
subfamily 3 3 0 0
sestrin family
family 3 0 1 1
shaker potassium channel beta subunit family
family 3 1 1 1
smoothelin family
family 3 0 1 0
snRNP core protein family
family 3 0 3 0
sphingomyelin synthase family
family 3 1 0 0
stereocilin family
family 3 0 0 0
sulfotransferase 6 family
family 3 0 0 0
synapsin family
family 3 0 1 0
synaptopodin family
family 3 0 0 0
synuclein family
family 3 1 1 1
S (TC 1.A.1.2) subfamily
subfamily 3 0 0 0
SLC41A transporter family
family 3 0 0 0
SLC43A transporter (TC 2.A.1.44) family
family 3 0 0 0
SLC46A family
family 3 1 0 0
SMARCD family
family 3 0 0 0
SMEK family
family 3 0 0 0
SNAP family
family 3 0 0 0
SNAP-25 family
family 3 0 3 2
SOGA family
family 3 0 0 0
SPT20 family
family 3 0 0 0
SRC/p160 nuclear receptor coactivator family
family 3 1 3 2
SS18 family
family 3 0 0 0
securin family
family 3 0 0 0
selectin/LECAM family
family 3 3 3 1
serine/threonine dehydratase family
family 3 1 3 2
SAA family
family 3 0 1 0
SAPS family
family 3 0 0 0
SYCE family
family 3 0 0 0
Spinster (TC 2.A.1.49) family
family 3 0 0 0
SCAR/WAVE family
family 3 0 2 0
SEZ6 family
family 3 0 1 0
SFT2 family
family 3 0 0 0
SH2B adapter family
family 3 0 1 0
SH3RF family
family 3 0 0 0
SINA (Seven in absentia) family
family 3 0 2 1
SLC34A transporter family
family 3 0 0 0
SEC16 family
family 2 0 0 0
SEC2 family
family 2 0 2 0
SERF family
family 2 0 0 0
SFTPA family
family 2 0 0 0
SGF11 family
family 2 0 1 0
SGT family
family 2 0 1 0
SH3BP5 family
family 2 0 1 0
SH3PXD2 family
family 2 0 1 0
SHANK family
family 2 0 1 0
SHMT family
family 2 1 2 1
SID1 family
family 2 0 0 0
SIKE family
family 2 0 0 0
SKAP family
family 2 0 2 1
SKP1 family
family 2 1 2 2
SLA2 family
family 2 0 2 1
SLAIN motif-containing family
family 2 0 1 0
SLC31A subfamily
subfamily 2 0 1 0
SLC35C subfamily
subfamily 2 0 0 0
SLRP class V subfamily
subfamily 2 0 0 0
SMC1 subfamily
subfamily 2 0 1 0
SWR1 subfamily
subfamily 2 0 0 0
SYK/ZAP-70 subfamily
subfamily 2 2 2 2
SmF/LSm6 subfamily
subfamily 2 0 2 0
Suvar4-20 subfamily
subfamily 2 2 2 2
sesquipedalian family
family 2 0 1 0
shugoshin family
family 2 0 1 0
sidekick family
family 2 0 1 1
slowmo family
family 2 0 1 1
snRNP SmB/SmN family
family 2 0 1 0
somatostatin family
family 2 1 1 0
speriolin family
family 2 0 0 0
spermidine/spermine synthase family
family 2 2 2 2
spire family
family 2 0 2 1
stanniocalcin family
family 2 0 0 0
succinate/malate CoA ligase beta subunit family
family 2 0 0 0
sulfatase-modifying factor family
family 2 0 2 2
sulfotransferase 3 family
family 2 0 0 0
synaptojanin family
family 2 0 2 0
synembryn family
family 2 0 0 0
SDE3 subfamily
subfamily 2 0 0 0
SEC23 subfamily
subfamily 2 0 1 1
SMARCC family
family 2 0 1 0
SMAUG family
family 2 0 0 0
SMIM11 family
family 2 0 0 0
SMN family
family 2 1 2 1
SNURF family
family 2 0 0 0
SOSS-B family
family 2 0 1 0
SPAG11 family
family 2 0 0 0
SPARC family
family 2 0 1 1
SPATA2 family
family 2 0 1 0
SPATA6 family
family 2 0 0 0
SPATS2 family
family 2 0 0 0
SPOT14 family
family 2 0 0 0
SPTSS family
family 2 0 0 0
SREBP family
family 2 1 2 0
ST7 family
family 2 0 0 0
STAM family
family 2 0 2 0
STOP family
family 2 0 0 0
STRIP family
family 2 0 0 0
STT3 family
family 2 0 0 0
SUI1 family
family 2 0 1 1
sarcoglycan alpha/epsilon family
family 2 0 0 0
sclerostin family
family 2 0 1 0
sel-1 family
family 2 0 1 1
selenophosphate synthase 1 family
family 2 0 1 1
selenoprotein M/SEP15 family
family 2 0 0 0
semenogelin family
family 2 0 0 0
seminal plasma protein family
family 2 0 0 0
SAC3 family
family 2 0 1 0
SAP30 family
family 2 0 2 0
SAR1 family
family 2 0 1 0
SYCP2 family
family 2 0 0 0
SecY/SEC61-alpha family
family 2 0 0 0
SerB family
family 2 0 1 1
Stoned B family
family 2 0 1 0
Su(H) family
family 2 0 1 1
SAS10 family
family 2 0 0 0
SBNO family
family 2 0 0 0
SCO1/2 family
family 2 0 2 2
SEC15 family
family 2 0 0 0
SAAL1 family
family 1 0 0 0
SABRE family
family 1 0 0 0
SAM50/omp85 family
family 1 0 0 0
SAMHD1 family
family 1 0 1 1
SAP130 family
family 1 1 0 0
SAP18 family
family 1 0 1 1
SARAF family
family 1 0 0 0
SARG family
family 1 0 0 0
SVBP family
family 1 0 0 0
SVIP family
family 1 0 0 0
SVP26 family
family 1 0 0 0
SWEET sugar transporter family
family 1 0 0 0
SWI5/SAE3 family
family 1 0 0 0
SWP1 family
family 1 0 0 0
SWS1 family
family 1 0 0 0
SWT1 family
family 1 0 0 0
SYF2 family
family 1 0 0 0
SYG1 (TC 2.A.94) family
family 1 0 1 0
SYS1 family
family 1 0 0 0
SZRD1 family
family 1 0 0 0
SecE/SEC61-gamma family
family 1 0 1 0
SepSecS family
family 1 0 1 1
Sigma family
family 1 1 1 1
Spartan family
family 1 0 1 0
Spindly family
family 1 0 0 0
Symplekin family
family 1 0 1 1
SAYP family
family 1 0 0 0
SCAI family
family 1 0 0 0
SCARA5 family
family 1 0 0 0
SCC2/Nipped-B family
family 1 0 0 0
SCC4/mau-2 family
family 1 0 0 0
SCF family
family 1 1 1 1
SCHIP1 family
family 1 0 0 0
SCOC family
family 1 0 1 0
SCRG1 family
family 1 0 0 0
SDA1 family
family 1 0 0 0
SDCCAG3 family
family 1 0 0 0
SDE2 family
family 1 0 0 0
SDHAF2 family
family 1 0 0 0
SDHAF4 family
family 1 0 0 0
SDO1/SBDS family
family 1 0 1 1
SDS22 family
family 1 0 0 0
SDS3 family
family 1 0 0 0
SEC10 family
family 1 0 0 0
SEC20 family
family 1 0 0 0
SEC3 family
family 1 0 0 0
SEC5 family
family 1 0 1 0
SEC61-beta family
family 1 0 1 0
SEC62 family
family 1 0 0 0
SEC8 family
family 1 0 0 0
SECTM family
family 1 0 0 0
SEN15 family
family 1 0 1 0
SEN54 family
family 1 0 0 0
SERAC1 family
family 1 0 0 0
SF3A2 family
family 1 0 0 0
SF3A3 family
family 1 0 1 0
SF3B1 family
family 1 0 1 0
SF3B4 family
family 1 0 1 0
SF3B5 family
family 1 0 1 0
SF3B6 family
family 1 0 1 1
SFI1 family
family 1 0 1 0
SFR1/MEI5 family
family 1 0 0 0
SFTPD family
family 1 1 1 0
SGF29 family
family 1 0 1 1
SGT1 family
family 1 0 1 0
SH3YL1 family
family 1 0 1 0
SHOC2 family
family 1 0 0 0
SHQ1 family
family 1 0 1 0
SIL1 family
family 1 0 0 0
SIN1 family
family 1 0 1 0
SKA1 family
family 1 0 1 0
SKA2 family
family 1 0 1 0
SKA3 family
family 1 0 1 0
SLBP family
family 1 0 1 0
SLC33A transporter family
family 1 0 0 0
SLC3A transporter family
family 1 0 1 1
SLMAP family
family 1 0 0 0
SLT11 family
family 1 0 1 0
SLU7 family
family 1 0 0 0
SLX1 family
family 1 0 0 0
SLX4 family
family 1 0 1 0
SLX4IP family
family 1 0 0 0
SMAGP family
family 1 0 0 0
SMAP family
family 1 0 0 0
SMCO4 family
family 1 0 0 0
SMCR7 family
family 1 0 1 1
SMDT1/EMRE family
family 1 0 0 0
SMG8 family
family 1 0 0 0
SMG9 family
family 1 0 0 0
SMIM1 family
family 1 0 0 0
SMIM12 family
family 1 0 0 0
SMIM13 family
family 1 0 0 0
SMIM15 family
family 1 0 0 0
SMIM19 family
family 1 0 0 0
SMIM4 family
family 1 0 0 0
SMIM7 family
family 1 0 0 0
SMIM8 family
family 1 0 0 0
SMP-30/CGR1 family
family 1 0 1 1
SMPX family
family 1 0 0 0
SMRP1 family
family 1 0 0 0
SNAPC3/SRD2 family
family 1 0 0 0
SNAPIN family
family 1 0 0 0
SNF5 family
family 1 0 1 0
SNF8 family
family 1 0 1 0
SNU66/SART1 family
family 1 0 1 0
SNUT3 family
family 1 0 0 0
SNW family
family 1 0 0 0
SOBP family
family 1 0 0 0
SOLO family
family 1 0 0 0
SOS response-associated peptidase family
family 1 0 1 0
SOSS-C family
family 1 0 1 0
SPAG8 family
family 1 0 0 0
SPATA16 family
family 1 0 0 0
SPATA24 family
family 1 0 0 0
SPATA25 family
family 1 0 0 0
SPATA45 family
family 1 0 0 0
SPC24 family
family 1 0 1 0
SPC25 family
family 1 0 1 0
SPCS1 family
family 1 0 0 0
SPCS2 family
family 1 0 0 0
SPCS3 family
family 1 0 0 0
SPE39 family
family 1 0 0 0
SPEC3 family
family 1 0 0 0
SPESP1 family
family 1 0 0 0
SPF27 family
family 1 0 0 0
SPO22 family
family 1 0 0 0
SPP2 family
family 1 0 0 0
SPRN family
family 1 0 0 0
SPT2 family
family 1 0 1 0
SPT3 family
family 1 0 0 0
SPT4 family
family 1 0 1 0
SPT5 family
family 1 0 1 0
SPT6 family
family 1 0 0 0
SQRD family
family 1 0 0 0
SRA1 family
family 1 0 1 0
SRCIN1 family
family 1 1 0 0
SRP receptor beta subunit family
family 1 0 0 0
SRP14 family
family 1 0 1 0
SRP19 family
family 1 0 1 1
SRP68 family
family 1 0 1 0
SRP72 family
family 1 0 0 0
SRP9 family
family 1 0 1 0
SRR1 family
family 1 0 0 0
SRY family
family 1 0 1 1
SSNA1 family
family 1 0 0 0
SSRP1 family
family 1 0 1 0
SSU72 phosphatase family
family 1 0 1 1
STIMATE family
family 1 0 0 0
STK11IP family
family 1 0 0 0
STK19 family
family 1 0 0 0
STN1 family
family 1 0 1 0
STPG1 family
family 1 0 0 0
SUA5 family
family 1 0 0 0
SUFU family
family 1 1 1 1
SURF1 family
family 1 0 0 0
SURF2 family
family 1 0 0 0
SURF4 family
family 1 0 0 0
SURF6 family
family 1 0 0 0
SVAP1 family
family 1 0 0 0
saccharopine dehydrogenase family
family 1 0 0 0
sarcolipin family
family 1 0 1 0
seipin family
family 1 0 0 0
selenium-binding protein family
family 1 0 0 0
selenoprotein K family
family 1 0 0 0
selenoprotein P family
family 1 0 0 0
selenoprotein S family
family 1 0 1 0
sepiapterin reductase family
family 1 0 1 1
serglycin family
family 1 0 0 0
serine-aspartate repeat-containing protein (SDr) family
family 1 0 0 0
shootin family
family 1 0 0 0
small G protein signaling modulator family
family 1 0 0 0
small membrane AKAP family
family 1 0 1 0
small mitochondrial proteolipid family
family 1 0 0 0
snurportin family
family 1 0 1 1
sodium channel auxiliary subunit SCN1B (TC 8.A.17) family
family 1 0 0 0
sodium channel auxiliary subunit SCN2B (TC 8.A.17) family
family 1 0 1 0
sodium channel auxiliary subunit SCN3B (TC 8.A.17) family
family 1 0 1 0
sodium channel auxiliary subunit SCN4B (TC 8.A.17) family
family 1 0 1 1
sororin family
family 1 0 0 0
squalene monooxygenase family
family 1 1 0 0
stannin family
family 1 0 1 1
stealth family
family 1 0 1 1
strictosidine synthase family
family 1 0 0 0
strumpellin family
family 1 0 0 0
succinate dehydrogenase/fumarate reductase iron-sulfur protein family
family 1 0 0 0
succinate/malate CoA ligase alpha subunit family
family 1 0 0 0
sulfiredoxin family
family 1 0 1 1
syndetin family
family 1 0 0 0
SCAMP5 subfamily
subfamily 1 0 0 0
SCN7A subfamily
subfamily 1 1 0 0
SCNN1A subfamily
subfamily 1 1 1 0
SCNN1B subfamily
subfamily 1 1 0 0
SCNN1D subfamily
subfamily 1 0 0 0
SCNN1G subfamily
subfamily 1 1 0 0
SCS7 subfamily
subfamily 1 0 0 0
SDHAF1 subfamily
subfamily 1 0 0 0
SDHAF3 subfamily
subfamily 1 0 0 0
SDR39U1 subfamily
subfamily 1 0 1 1
SELT subfamily
subfamily 1 0 0 0
SELW subfamily
subfamily 1 0 0 0
SET7 subfamily
subfamily 1 1 1 1
SETD3 subfamily
subfamily 1 0 1 1
SETD6 subfamily
subfamily 1 0 1 1
SHISA9 subfamily
subfamily 1 0 0 0
SLC1A1 subfamily
subfamily 1 1 0 0
SLC1A2 subfamily
subfamily 1 1 0 0
SLC1A3 subfamily
subfamily 1 1 0 0
SLC1A4 subfamily
subfamily 1 0 0 0
SLC1A5 subfamily
subfamily 1 0 0 0
SLC1A6 subfamily
subfamily 1 1 0 0
SLC1A7 subfamily
subfamily 1 1 0 0
SLC25A38 subfamily
subfamily 1 0 0 0
SLC38A9 subfamily
subfamily 1 0 0 0
SLC40A subfamily
subfamily 1 0 0 0
SLC6A1 subfamily
subfamily 1 1 0 0
SLC6A11 subfamily
subfamily 1 1 0 0
SLC6A12 subfamily
subfamily 1 1 0 0
SLC6A13 subfamily
subfamily 1 1 0 0
SLC6A14 subfamily
subfamily 1 0 0 0
SLC6A15 subfamily
subfamily 1 0 0 0
SLC6A16 subfamily
subfamily 1 0 0 0
SLC6A17 subfamily
subfamily 1 0 0 0
SLC6A18 subfamily
subfamily 1 0 0 0
SLC6A19 subfamily
subfamily 1 0 0 0
SLC6A2 subfamily
subfamily 1 1 0 0
SLC6A20 subfamily
subfamily 1 0 0 0
SLC6A3 subfamily
subfamily 1 1 0 0
SLC6A4 subfamily
subfamily 1 1 1 1
SLC6A5 subfamily
subfamily 1 1 0 0
SLC6A6 subfamily
subfamily 1 1 0 0
SLC6A7 subfamily
subfamily 1 0 0 0
SLC6A8 subfamily
subfamily 1 0 0 0
SLC6A9 subfamily
subfamily 1 1 0 0
SMARCAL1 subfamily
subfamily 1 0 1 0
SMC2 subfamily
subfamily 1 0 1 1
SMC3 subfamily
subfamily 1 0 0 0
SMC4 subfamily
subfamily 1 0 1 1
SMC5 subfamily
subfamily 1 0 0 0
SMC6 subfamily
subfamily 1 0 0 0
SORL1 subfamily
subfamily 1 0 1 1
SORT1 subfamily
subfamily 1 1 1 1
SOSS-B1 subfamily
subfamily 1 0 1 0
SOSS-B2 subfamily
subfamily 1 0 0 0
SPB1 subfamily
subfamily 1 0 0 0
SPERT subfamily
subfamily 1 0 0 0
SPT16 subfamily
subfamily 1 0 1 1
SPTSSA subfamily
subfamily 1 0 0 0
SPTSSB subfamily
subfamily 1 0 0 0
SRP54 subfamily
subfamily 1 0 1 1
SelB subfamily
subfamily 1 0 1 1
SerC subfamily
subfamily 1 0 1 1
Spastin subfamily
subfamily 1 0 1 0
Sphingosine-1-phosphate lyase subfamily
subfamily 1 1 1 0
Stum subfamily
subfamily 1 0 0 0