Browse Protein Families
Browse canSAR    »        »    


0 - 1 - 2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z - ALL

Family Level # members # members with tested compounds # members with 3D structures # members with Druggable 3D structures
protein kinase superfamily
superfamily 486 411 314 256
peptidase S1 family
family 120 54 55 40
protein-tyrosine phosphatase family
family 93 40 68 32
peptidase C19 family
family 76 12 25 7
potassium channel family
family 44 19 15 5
paired homeobox family
family 40 0 8 1
PRAME family
family 25 0 0 0
peptidase M14 family
family 23 6 9 7
peptidase M10A family
family 23 19 12 8
PI3/PI4-kinase family
family 20 16 14 13
PMP-22/EMP/MP20 family
family 19 0 0 0
PP2C family
family 17 3 3 3
POU transcription factor family
family 16 3 5 1
peptidase C2 family
family 15 2 6 3
peptidase C1 family
family 15 9 9 7
PPP phosphatase family
family 14 5 7 4
pancreatic ribonuclease family
family 13 3 7 3
peptidase M1 family
family 13 8 6 6
peptidase C14A family
family 13 12 8 7
PA-phosphatase related phosphoesterase family
family 12 0 0 0
peptidase A2 family
family 12 0 0 0
PKC subfamily
subfamily 12 11 10 7
phospholipase A2 family
family 12 10 4 3
peptidase T1B family
family 11 11 10 7
protein disulfide isomerase family
family 11 1 8 4
plexin family
family 11 0 6 2
peptidase A1 family
family 10 8 8 8
peptidase S8 family
family 10 10 2 2
PMG family
family 10 0 0 0
peptidase M28 family
family 9 2 4 4
POTE family
family 9 0 0 0
Protein arginine N-methyltransferase family
family 9 6 6 5
PDGF/VEGF growth factor family
family 9 4 7 0
PNMA family
family 9 0 0 0
peptidase T1A family
family 8 8 7 7
peptidase S54 family
family 8 0 1 0
patched family
family 8 2 2 1
polycystin family
family 8 0 3 1
plakin or cytolinker family
family 7 0 5 3
peptidase M13 family
family 7 2 2 2
peptidase M16 family
family 7 2 4 4
POM121 family
family 7 0 1 0
PPIase A subfamily
subfamily 7 1 1 1
protease inhibitor I39 (alpha-2-macroglobulin) family
family 7 0 1 1
peptidase C48 family
family 7 5 4 2
P2X receptor family
family 7 7 1 1
phosphoglycerate mutase family
family 6 0 4 2
PtdIns transfer protein family
family 6 1 1 1
prefoldin subunit beta family
family 6 0 0 0
peptidase S9B family
family 6 4 6 6
potassium channel KCNE family
family 6 1 3 1
peroxidase family
family 6 4 1 1
peptidase M12A family
family 6 1 3 1
peroxiredoxin family
family 6 1 6 3
phospholipase D family
family 6 2 0 0
peptidase M67A family
family 6 1 5 3
prickle / espinas / testin family
family 5 0 1 0
Plunc family
family 5 0 1 0
peroxisomal membrane protein PXMP2/4 family
family 5 0 0 0
polyadenylate-binding protein type-1 family
family 5 1 2 1
protein arginine deiminase family
family 5 4 4 3
peptidase A22B family
family 5 0 0 0
PP-1 subfamily
subfamily 5 3 4 2
PTR2/POT transporter (TC 2.A.17) family
family 5 2 0 0
PRR23 family
family 5 0 0 0
phosphohexose mutase family
family 5 0 1 1
PDK/BCKDK protein kinase family
family 5 4 4 4
perilipin family
family 5 0 0 0
phospholipid scramblase family
family 5 0 2 0
peptidase MINDY family
family 5 0 1 1
Plasminogen subfamily
subfamily 5 3 4 2
phosphatase 2A regulatory subunit B56 family
family 5 1 1 1
peptidase M20A family
family 5 0 3 2
peptidase C65 family
family 4 0 3 3
protease inhibitor I35 (TIMP) family
family 4 0 3 2
phosphatase and actin regulator family
family 4 0 1 0
peptidase C54 family
family 4 0 2 1
Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily
subfamily 4 0 0 0
phosducin family
family 4 0 1 0
paralemmin family
family 4 0 0 0
parvalbumin family
family 4 0 2 0
potassium channel KCNN family
family 4 4 2 1
PDE4 subfamily
subfamily 4 4 4 4
PIH1 family
family 4 0 1 0
peptidase S1C family
family 4 0 3 3
peptidase M24B family
family 4 3 3 2
peptidase C12 family
family 4 2 3 2
PATE family
family 4 0 0 0
phosphatase 2A regulatory subunit B family
family 4 1 1 1
peptidase C64 family
family 4 0 4 2
Piwi subfamily
subfamily 4 0 2 0
PIAS family
family 4 0 3 2
Pelle subfamily
subfamily 4 3 4 2
pyrroline-5-carboxylate reductase family
family 4 0 1 1
pecanex family
family 4 0 0 0
potassium channel HCN family
family 4 4 3 3
protein phosphatase inhibitor 2 family
family 4 0 0 0
PP1 inhibitor family
family 4 0 0 0
profilin family
family 4 0 2 0
PC-esterase family
family 4 0 0 0
prokaryotic/mitochondrial release factor family
family 4 0 1 0
pseudouridine synthase RluA family
family 4 0 2 0
PA28 family
family 3 0 1 0
PAR6 family
family 3 0 1 0
PACSIN family
family 3 0 2 0
peptidase C69 family
family 3 0 0 0
popeye family
family 3 0 0 0
protein prenyltransferase subunit beta family
family 3 2 1 1
paired-like homeobox family
family 3 0 0 0
parvin family
family 3 1 2 1
poly(A) polymerase family
family 3 0 1 1
PKI family
family 3 0 1 0
pentraxin family
family 3 1 2 2
phosphofructokinase type A (PFKA) family
family 3 1 2 2
parathyroid hormone family
family 3 0 2 1
PI3K p85 subunit family
family 3 1 2 1
Polycystin subfamily
subfamily 3 0 2 2
PROL1/PROL3 family
family 3 0 0 0
peptidase M24A family
family 3 2 2 2
p53 family
family 3 1 3 3
pseudouridine synthase TruB family
family 3 0 0 0
PEPP subfamily
subfamily 3 0 0 0
protein prenyltransferase subunit alpha family
family 3 1 1 1
pannexin family
family 3 0 0 0
PP-2B subfamily
subfamily 3 2 2 1
peptidase S10 family
family 3 2 1 1
peroxin-11 family
family 3 0 0 0
P4HA family
family 3 2 1 0
PIGG/PIGN/PIGO family
family 3 0 0 0
peptidase M3 family
family 3 0 2 2
phosphatidylethanolamine-binding protein family
family 3 0 2 1
paxillin family
family 3 1 2 0
PI transfer class IIA subfamily
subfamily 3 1 0 0
Plasma kallikrein subfamily
subfamily 3 2 2 2
PAR subfamily
subfamily 3 0 0 0
phosphorylase b kinase regulatory chain family
family 3 3 0 0
PLAC1 family
family 3 0 0 0
PA-PLA1 family
family 3 0 0 0
pellino family
family 3 0 1 1
paraoxonase family
family 3 1 0 0
Peptidase M19 family
family 3 1 1 0
PDE1 subfamily
subfamily 3 3 1 1
PIM subfamily
subfamily 3 3 2 2
pex2/pex10/pex12 family
family 3 0 0 0
purine/pyrimidine phosphoribosyltransferase family
family 3 1 3 2
PUR DNA-binding protein family
family 3 0 0 0
protein phosphatase inhibitor 1 family
family 3 0 0 0
PKD subfamily
subfamily 3 3 2 0
peptidase S26B family
family 3 0 0 0
PRA1 family
family 3 0 0 0
peptidase S28 family
family 3 2 2 2
Polycomblike family
family 3 0 3 2
peptidase S33 family
family 3 1 0 0
PDE6D/unc-119 family
family 3 1 2 2
PCP4 family
family 2 0 1 0
pro/parathymosin family
family 2 0 1 0
PROTOR family
family 2 0 0 0
proline oxidase family
family 2 0 0 0
pleiotrophin family
family 2 1 2 0
PPP1R15 family
family 2 0 2 0
Prune subfamily
subfamily 2 1 0 0
PMEPA1 family
family 2 0 0 0
PPIL1 subfamily
subfamily 2 0 2 1
PRR15 family
family 2 0 0 0
prominin family
family 2 0 0 0
PRP38 family
family 2 0 1 1
PTH2 family
family 2 0 1 0
PHYHIP family
family 2 0 0 0
Purple acid phosphatase family
family 2 0 1 0
pyruvate kinase family
family 2 2 2 2
peptidase C15 family
family 2 0 0 0
PIEZO (TC 1.A.75) family
family 2 0 0 0
PDE3 subfamily
subfamily 2 2 1 1
pterin-4-alpha-carbinolamine dehydratase family
family 2 0 2 0
PX domain-containing GAP family
family 2 0 1 0
peptidase M24 family
family 2 0 2 2
Prospero homeodomain family
family 2 0 1 1
PNP/MTAP phosphorylase family
family 2 2 2 2
PDE8 subfamily
subfamily 2 2 1 1
Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
subfamily 2 2 1 1
peptidase S16 family
family 2 0 1 1
prefoldin subunit alpha family
family 2 0 0 0
peptidase S26 family
family 2 0 0 0
p23/wos2 family
family 2 0 1 0
peptidase C13 family
family 2 1 1 1
PACS family
family 2 0 0 0
PAR3 family
family 2 0 1 0
PNP/UDP phosphorylase family
family 2 1 2 1
PhyH family
family 2 0 2 2
prohibitin family
family 2 0 0 0
PP-5 (PP-T) subfamily
subfamily 2 0 1 1
podocalyxin family
family 2 0 0 0
PDS5 family
family 2 0 1 1
phosphoenolpyruvate carboxykinase [GTP] family
family 2 1 1 1
PHOSPHO family
family 2 1 0 0
peptidase M67C family
family 2 0 2 2
PNRC family
family 2 0 1 0
PPDPF family
family 2 0 0 0
prostaglandin G/H synthase family
family 2 2 1 1
phosphatidyl serine synthase family
family 2 0 0 0
PI transfer class I subfamily
subfamily 2 0 1 1
peroxiredoxin-like FAM213 family
family 2 0 0 0
PPase class C family
family 2 1 0 0
PMEL/NMB family
family 2 0 1 0
PSD family
family 2 0 0 0
PAIP2 family
family 2 0 1 0
protease inhibitor I47 (latexin) family
family 2 0 1 0
pyrimidine 5'-nucleotidase family
family 2 0 1 1
peptidase C78 family
family 2 0 0 0
PPase family
family 2 0 0 0
peptidase S9A family
family 2 2 1 1
PDE7 subfamily
subfamily 2 2 1 1
Proboscipedia subfamily
subfamily 2 0 0 0
pseudouridine synthase TruD family
family 2 0 1 1
PRPH2/ROM1 family
family 2 0 0 0
prenylcysteine oxidase family
family 2 0 0 0
peroxisomal targeting signal receptor family
family 2 0 1 1
peptidase A22A family
family 2 2 1 1
peptidase M2 family
family 2 2 2 2
palmitoyl-protein thioesterase family
family 2 2 2 0
phosphoglycerate kinase family
family 2 2 1 1
peptidase M54 family
family 2 0 0 0
phosphatase 2A regulatory subunit A family
family 2 0 1 1
prion family
family 2 1 2 1
PDPK1 subfamily
subfamily 2 1 1 1
PICALM/SNAP91 family
family 2 0 1 0
peptidase C56 family
family 2 0 1 0
PRPF40 family
family 2 0 1 0
phospholipase B-like family
family 2 0 0 0
PAT1 family
family 2 0 1 0
protein sulfotransferase family
family 2 1 2 2
peptidase M43B family
family 2 0 0 0
peptidase M17 family
family 2 1 0 0
PDE9 subfamily
subfamily 1 1 1 1
peroxin-13 family
family 1 0 0 0
proline racemase family
family 1 0 0 0
PR/SET subfamily
subfamily 1 1 1 1
PYROXD1 subfamily
subfamily 1 0 0 0
PPP1R35 family
family 1 0 0 0
peptidase C85 family
family 1 0 1 1
peroxin-19 family
family 1 0 1 1
PET117 family
family 1 0 0 0
PTCD2 family
family 1 0 0 0
PIGO subfamily
subfamily 1 0 0 0
peptidase M8 family
family 1 0 0 0
peptidase M18 family
family 1 1 1 0
pyridoxal phosphate-binding protein YggS/PROSC family
family 1 0 0 0
PHAX family
family 1 0 1 0
PPIase E subfamily
subfamily 1 0 1 0
peptidase S12 family
family 1 0 0 0
PSD-B subfamily
subfamily 1 0 0 0
proteasome inhibitor PI31 family
family 1 0 1 1
PIGP family
family 1 0 0 0
PPR family
family 1 0 1 1
PPIase D subfamily
subfamily 1 1 0 0
PRMT6 subfamily
subfamily 1 1 1 1
PRRC1 family
family 1 0 0 0
PAN3 family
family 1 0 0 0
PPIL4 subfamily
subfamily 1 0 0 0
PSMG4 family
family 1 0 1 0
PCDP1 family
family 1 0 0 0
PBDC1 family
family 1 0 0 0
PDAP1 family
family 1 0 0 0
PPIase H subfamily
subfamily 1 0 1 1
proteasome subunit S11 family
family 1 0 1 1
PIGQ family
family 1 0 0 0
Pi family
family 1 1 1 1
PPP1R37 family
family 1 0 0 0
PRP18 family
family 1 0 1 1
PAL/histidase family
family 1 1 0 0
PRP31 family
family 1 0 1 1
proteasome subunit S14 family
family 1 0 1 1
Prx6 subfamily
subfamily 1 0 1 0
PIGX family
family 1 0 0 0
peroxin-14 family
family 1 0 1 1
PrpD family
family 1 0 0 0
peptidase S41A family
family 1 0 0 0
proteasome subunit S9 family
family 1 0 1 1
PIGF family
family 1 0 0 0
PRP16 sub-subfamily
subsubfamily 1 0 0 0
PPC synthetase family
family 1 0 1 1
PLAC9 family
family 1 0 0 0
PSMG1 family
family 1 0 0 0
PARM family
family 1 0 0 0
pescadillo family
family 1 0 1 0
PNRC1 subfamily
subfamily 1 0 0 0
PDCD5 family
family 1 0 1 0
PDE2 subfamily
subfamily 1 1 1 1
Prostamide/prostaglandin F synthase subfamily
subfamily 1 0 0 0
peroxin-3 family
family 1 0 1 0
p22phox family
family 1 0 1 0
pICln (TC 1.A.47) family
family 1 0 0 0
paladin family
family 1 0 0 0
PSMG3 family
family 1 1 1 1
POMC family
family 1 0 1 0
PDCD10 family
family 1 0 1 1
PINX1 family
family 1 0 0 0
protoporphyrinogen oxidase family
family 1 1 1 1
phytoene/squalene synthase family
family 1 1 1 1
PIGT family
family 1 0 0 0
PIGH family
family 1 0 0 0
PROCA1 family
family 1 0 0 0
PP-6 (PP-V) subfamily
subfamily 1 0 0 0
peptidase S9C family
family 1 1 0 0
PIGC family
family 1 0 0 0
proteasome subunit p55 family
family 1 0 1 1
phospholamban family
family 1 0 1 0
PEMT/PEM2 methyltransferase family
family 1 0 0 0
peptidase M48 family
family 1 0 0 0
podoplanin family
family 1 0 1 0
PIGM family
family 1 0 0 0
PPIase B subfamily
subfamily 1 1 1 0
PIGV family
family 1 0 0 0
polyribonucleotide nucleotidyltransferase family
family 1 0 1 1
pyridoxine kinase family
family 1 1 1 1
PMAIP1 family
family 1 0 1 0
protease inhibitor I27 (calpastatin) family
family 1 0 0 0
protein lines family
family 1 0 0 0
PIGZ subfamily
subfamily 1 0 0 0
PP-4 (PP-X) subfamily
subfamily 1 0 0 0
periaxin family
family 1 0 1 0
PRORSD1 family
family 1 0 0 0
PTCD1 family
family 1 0 0 0
Phosphotriesterase family
family 1 0 0 0
PGAP2IP family
family 1 0 0 0
PNRC2 subfamily
subfamily 1 0 1 0
PEN-2 family
family 1 1 1 0
PRKRA family
family 1 0 1 0
pirin family
family 1 1 1 1
papilin family
family 1 0 0 0
PIP family
family 1 0 1 0
PIGS family
family 1 0 0 0
PITHD1 family
family 1 0 0 0
POC5 family
family 1 0 0 0
PCH2 subfamily
subfamily 1 0 1 1
PTH family
family 1 0 0 0
phage and mitochondrial RNA polymerase family
family 1 1 1 1
PAN2 subfamily
subfamily 1 0 0 0
PRMT8 subfamily
subfamily 1 1 1 1
peptidase M50A family
family 1 0 0 0
PBTF family
family 1 1 1 1
pym family
family 1 0 0 0
PHYHD1 subfamily
subfamily 1 0 1 1
proteasome subunit S3 family
family 1 0 1 1
PNGase family
family 1 0 1 0
POU2AF1 family
family 1 0 1 0
proteasome subunit S5B/HSM3 family
family 1 0 0 0
peptidase M67 family
family 1 0 0 0
PIN4 subfamily
subfamily 1 1 1 0
PPIL2 subfamily
subfamily 1 0 1 0
pinin family
family 1 0 0 0
PIGG subfamily
subfamily 1 0 0 0
PPP4R2 family
family 1 0 0 0
PHLDA3 family
family 1 0 0 0
Parkin subfamily
subfamily 1 0 1 1
POMP/UMP1 family
family 1 0 0 0
peptidase C26 family
family 1 1 1 1
PIGL family
family 1 0 0 0
PTOV1 subfamily
subfamily 1 0 0 0
PTPA-type PPIase family
family 1 1 1 1
PIF1 subfamily
subfamily 1 0 1 1
PHLDA2 family
family 1 0 0 0
proteasome subunit S2 family
family 1 0 1 1
PhzF family
family 1 0 0 0
pectinacetylesterase family
family 1 0 1 1
PDCD4 family
family 1 1 1 1
PGAP2 family
family 1 0 0 0
PIGB subfamily
subfamily 1 0 0 0
Phe-tRNA synthetase alpha subunit type 2 subfamily
subfamily 1 0 1 1
PI transfer class IIB subfamily
subfamily 1 0 0 0
Pelota subfamily
subfamily 1 0 1 0
PIGW family
family 1 0 0 0
proteasome subunit S10 family
family 1 0 1 1
phenylalanyl-tRNA synthetase beta subunit family
family 1 0 1 1
P33MONOX family
family 1 0 0 0
peptidase M48A family
family 1 0 1 1
PIGN subfamily
subfamily 1 0 0 0
PRKRIP1 family
family 1 0 0 0
peptidase U48 family
family 1 1 0 0
PP3/GlyCAM-1 family
family 1 0 0 0
PET100 family
family 1 0 0 0
PSPC family
family 1 0 1 0
P subfamily
subfamily 1 0 1 1
PAF1 family
family 1 0 1 1
peptidase M49 family
family 1 1 1 1
PreP subfamily
subfamily 1 1 1 1
PET191 family
family 1 0 0 0
PTPS family
family 1 0 1 0
PPIL3 subfamily
subfamily 1 0 1 0
PRP39 family
family 1 0 0 0
PLEKHD1 family
family 1 0 0 0
proteasome subunit S5A family
family 1 0 1 1
PREY family
family 1 0 0 0
PrmA family
family 1 0 0 0
protamine P2 family
family 1 0 0 0
PTRHD1 subfamily
subfamily 1 0 0 0
pyridoxamine 5'-phosphate oxidase family
family 1 1 1 0
polyprenol kinase family
family 1 0 0 0
poly(ADP-ribose) glycohydrolase family
family 1 1 1 1
P-Pant transferase superfamily
superfamily 1 1 1 1
polypeptide deformylase family
family 1 1 1 1
PSMG2 family
family 1 0 0 0
phosphatidylserine decarboxylase family
family 1 0 0 0
peroxin-16 family
family 1 0 0 0
protein N5-glutamine methyltransferase family
family 1 0 0 0
proteasome subunit S1 family
family 1 1 1 1
protamine P3 family
family 1 0 0 0
peptidase S14 family
family 1 0 1 0
peptidase C14B family
family 1 1 1 1
PNO1 family
family 1 0 0 0
Polyprenol reductase subfamily
subfamily 1 0 0 0
PCD1 subfamily
subfamily 1 0 1 1
PHF5 family
family 1 0 1 1
PER33/POM33 family
family 1 0 0 0
PRMT7 subfamily
subfamily 1 0 0 0
Porcupine subfamily
subfamily 1 1 0 0
PIGU family
family 1 0 0 0
PARI family
family 1 0 0 0
PHF23 family
family 1 1 0 0
PpiC/parvulin rotamase family
family 1 1 1 0
PSRC1 family
family 1 0 0 0
Prx5 subfamily
subfamily 1 0 1 1
PGAP3 family
family 1 0 0 0
PurH family
family 1 1 1 1
pseudouridine synthase Pus10 family
family 1 0 1 1
peptidase S1B family
family 1 0 0 0
PSMD14 subfamily
subfamily 1 1 1 1
peptidase M76 family
family 1 0 0 0
proteasome subunit p27 family
family 1 0 0 0
peroxin-26 family
family 1 0 0 0
PCNA family
family 1 1 1 1
protamine P1 family
family 1 0 0 0
Phospholipase B1 subfamily
subfamily 1 0 0 0
PCM1 family
family 1 0 0 0