Browse Protein Families
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0 - 1 - 2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z - ALL

Family Level # members # members with tested compounds # members with 3D structures # members with Druggable 3D structures
MHC class I family
family 85 1 40 35
major facilitator superfamily
superfamily 76 16 4 2
mitochondrial carrier (TC 2.A.29) family
family 53 1 3 1
methyltransferase superfamily
superfamily 43 1 16 13
Myosin family
family 37 1 14 10
MHC class II family
family 27 2 15 5
major facilitator (TC 2.A.1) superfamily
superfamily 23 12 0 0
metallo-dependent hydrolases superfamily
superfamily 23 8 14 7
MAP kinase kinase kinase subfamily
subfamily 18 17 13 9
MAGUK family
family 18 3 15 9
MS4A family
family 16 1 1 0
MIP/aquaporin (TC 1.A.8) family
family 15 1 4 3
Monocarboxylate porter (TC 2.A.1.13) family
family 14 3 0 0
monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
family 14 4 1 0
metallothionein superfamily
superfamily 14 0 2 0
MAP kinase subfamily
subfamily 14 14 11 11
metallo-beta-lactamase superfamily
superfamily 11 1 7 4
membrane-bound acyltransferase family
family 11 4 0 0
Mas subfamily
subfamily 9 2 0 0
MAP kinase kinase subfamily
subfamily 8 8 7 5
MCM family
family 8 0 2 0
MOB1/phocein family
family 7 0 2 2
M28B subfamily
subfamily 7 2 4 4
Maf subfamily
subfamily 6 1 1 1
MAPEG family
family 6 6 3 1
MAL family
family 6 0 0 0
MBD3L family
family 6 0 0 0
Mu family
family 5 5 4 2
MYST (SAS/MOZ) family
family 5 4 5 4
multicopper oxidase family
family 5 2 3 2
mab-21 family
family 5 0 2 2
MNB/DYRK subfamily
subfamily 5 5 3 3
Muscarinic acetylcholine receptor subfamily
subfamily 5 5 4 2
METTL21 family
family 5 0 4 4
MyBP family
family 5 0 3 0
Multidrug resistance exporter (TC 3.A.1.201) subfamily
subfamily 5 4 1 1
metallophosphoesterase superfamily
superfamily 5 0 1 0
myelin P0 protein family
family 4 0 1 1
mTERF family
family 4 0 3 1
mastermind family
family 4 0 1 0
MiT/TFE family
family 4 0 1 0
MAP7 family
family 4 0 0 0
METL family
family 4 0 0 0
MIA/OTOR family
family 4 0 2 1
MEF2 family
family 4 0 2 0
MAPR subfamily
subfamily 4 0 1 0
myozenin family
family 3 0 0 0
MIF family
family 3 1 3 3
myelin proteolipid protein family
family 3 0 1 0
melanin-concentrating hormone family
family 3 0 0 0
MPI phosphatase family
family 3 3 3 2
MHC peptide exporter (TC 3.A.1.209) subfamily
subfamily 3 1 2 2
myotilin/palladin family
family 3 0 2 1
MICU1 family
family 3 0 1 1
MsrB Met sulfoxide reductase family
family 3 0 1 0
MT-A70-like family
family 3 0 2 2
muscleblind family
family 3 0 2 0
MTFR1 family
family 3 0 0 0
MAPRE family
family 3 0 2 2
Mical family
family 3 0 3 0
MCF2 family
family 3 0 0 0
MDFI family
family 3 0 0 0
MCAK/KIF2 subfamily
subfamily 3 1 2 2
MEGF family
family 3 0 0 0
mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family
family 3 0 0 0
Mrp/NBP35 ATP-binding proteins family
family 3 0 0 0
MYT1 family
family 3 1 2 0
malic enzymes family
family 3 2 2 2
MORF4 family-associated protein family
family 3 0 0 0
metaxin family
family 3 0 0 0
MAP1 family
family 3 1 0 0
mesothelin family
family 2 0 1 0
mitochondrial Rho GTPase family
family 2 0 2 2
Mediator complex subunit 13 family
family 2 0 0 0
mitoguardin family
family 2 0 0 0
MRL family
family 2 0 2 0
MIP18 family
family 2 0 1 0
Mediator complex subunit 25 family
family 2 0 1 1
MCAF family
family 2 0 1 0
MICOS complex subunit Mic19 family
family 2 0 0 0
Msh homeobox family
family 2 0 1 0
MOZART2 family
family 2 0 0 0
MDH type 2 family
family 2 1 0 0
MCU (TC 1.A.77) family
family 2 0 1 1
MCRIP family
family 2 0 0 0
motilin family
family 2 1 1 0
meteorin family
family 2 0 0 0
MTSS1 family
family 2 0 1 0
MFSD6 family
family 2 0 0 0
MFAP family
family 2 0 0 0
Mo25 family
family 2 0 2 1
methylthiotransferase family
family 2 0 0 0
mis18 family
family 2 0 0 0
mago nashi family
family 2 0 2 2
MDM2/MDM4 family
family 2 2 2 2
MCC family
family 2 0 0 0
MIC subfamily
subfamily 2 0 2 2
MARCKS family
family 2 0 0 0
MVB12 family
family 2 0 1 0
multiplexin collagen family
family 2 0 2 0
Mitofusin subfamily
subfamily 2 0 1 1
MUM1 family
family 2 0 1 0
MRAP family
family 2 0 0 0
MRF family
family 2 0 1 1
multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family
family 2 2 0 0
Methionine aminopeptidase type 1 subfamily
subfamily 2 1 1 1
Musashi family
family 2 0 1 0
MON1/SAND family
family 2 0 0 0
MCTP family
family 2 0 1 0
Mediator complex subunit 12 family
family 2 0 0 0
MISP family
family 2 0 0 0
MLF family
family 2 0 1 0
MsrA Met sulfoxide reductase family
family 1 0 0 0
Methionine aminopeptidase eukaryotic type 2 subfamily
subfamily 1 1 1 1
MRNIP family
family 1 0 0 0
macoilin family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL45 family
family 1 0 1 1
mitochondrion-specific ribosomal protein mS27 family
family 1 0 0 0
Mediator complex subunit 16 family
family 1 0 0 0
METTL18 family
family 1 0 1 0
MAX family
family 1 1 1 0
midasin family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL40 family
family 1 0 1 0
MICOS complex subunit Mic10 family
family 1 0 0 0
Mediator complex subunit 28 family
family 1 0 0 0
METTL23 family
family 1 0 0 0
myotrophin family
family 1 0 1 0
MSL2 family
family 1 0 1 0
Monothiol subfamily
subfamily 1 0 1 0
maelstrom family
family 1 0 1 0
MRE11/RAD32 family
family 1 0 1 1
METTL16/RlmF family
family 1 0 1 1
MYCT1 family
family 1 0 0 0
Mevalonate kinase subfamily
subfamily 1 0 1 1
Mediator complex subunit 29 family
family 1 0 0 0
MOZART1 family
family 1 0 0 0
Mitochondrion-specific ribosomal protein mL38 subfamily
subfamily 1 0 1 1
MADD family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL49 family
family 1 0 1 0
MCOLN1 sub-subfamily
subsubfamily 1 0 1 1
Mediator complex subunit 7 family
family 1 0 0 0
MAK3 subfamily
subfamily 1 0 0 0
mannose-6-phosphate isomerase type 1 family
family 1 1 0 0
MAT2B subfamily
subfamily 1 0 1 1
MAK10 family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL42 family
family 1 0 1 0
MGME1 family
family 1 0 0 0
MELT/VEPH family
family 1 0 0 0
MRL1/IGF2R family
family 1 1 1 1
Mediator complex subunit 31 family
family 1 0 0 0
MMS22L subfamily
subfamily 1 0 0 0
MPP10 family
family 1 0 0 0
Mediator complex subunit 24 family
family 1 0 0 0
MitoPLD/Zucchini subfamily
subfamily 1 0 0 0
mandelate racemase/muconate lactonizing enzyme family
family 1 0 1 0
MOCOS subfamily
subfamily 1 0 0 0
Mediator complex subunit 4 family
family 1 0 0 0
MCOLN3 sub-subfamily
subsubfamily 1 0 1 1
MEIOB family
family 1 0 0 0
mut-7 family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL46 family
family 1 0 1 1
Mediator complex subunit 21 family
family 1 0 0 0
MoaE family
family 1 0 1 0
MCOLN2 sub-subfamily
subsubfamily 1 0 0 0
Mediator complex subunit 26 family
family 1 0 1 0
mitochondrion-specific ribosomal protein mS25 family
family 1 0 0 0
Mediator complex subunit 11 family
family 1 0 0 0
MTBP family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL53 family
family 1 0 1 0
methyltransferase TRM13 family
family 1 0 0 0
malectin family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL55 family
family 1 0 1 0
MIEAP family
family 1 0 0 0
MISS family
family 1 0 0 0
MTG1 subfamily
subfamily 1 0 0 0
MDM20/NAA25 family
family 1 0 0 0
membralin family
family 1 0 0 0
MGMT family
family 1 1 1 1
MSOX/MTOX family
family 1 1 0 0
mitochondrion-specific ribosomal protein mS23 family
family 1 0 0 0
MAD2L1BP family
family 1 0 1 0
MYSM1 subfamily
subfamily 1 0 1 0
Monoacylglycerol lipase family
family 1 1 1 1
MIF4GD family
family 1 0 0 0
MiaB subfamily
subfamily 1 0 0 0
MID49/MID51 family
family 1 0 0 0
Mediator complex subunit 6 family
family 1 0 0 0
melanoregulin family
family 1 0 0 0
MUSTANG family
family 1 0 0 0
mitochondrion-specific ribosomal protein mS22 family
family 1 0 0 0
MTUS1 family
family 1 0 0 0
MasA/MtnC family
family 1 0 1 1
MICOS complex subunit Mic13 family
family 1 0 0 0
Mediator complex subunit 10 family
family 1 0 0 0
MMS22 family
family 1 0 0 0
MSANTD3 family
family 1 0 0 0
mitochondrion-specific ribosomal protein mS29 family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL50 family
family 1 0 1 0
mitochondrion-specific ribosomal protein mL65 family
family 1 0 1 1
Mitochondrion-specific ribosomal protein mL62 subfamily
subfamily 1 0 1 0
MOCS2B subfamily
subfamily 1 0 1 0
MEIG1 family
family 1 0 0 0
MtnA subfamily
subfamily 1 0 1 1
Mediator complex subunit 15 family
family 1 0 1 0
MLLT11 family
family 1 0 0 0
MtnB subfamily
subfamily 1 0 1 0
MTFP1 family
family 1 0 0 0
myo-inositol oxygenase family
family 1 0 1 0
MnmG family
family 1 0 0 0
MAM33 family
family 1 0 1 0
MFAP1 family
family 1 0 1 0
MYMX family
family 1 0 0 0
MZB1 family
family 1 0 0 0
MNS1 family
family 1 0 0 0
MET18/MMS19 family
family 1 0 0 0
Mediator complex subunit 18 family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL41 family
family 1 0 1 0
MCM10 family
family 1 0 0 0
Mitochondrion-specific ribosomal protein mL66 subfamily
subfamily 1 0 1 0
MOG1 family
family 1 0 1 0
METTL22 family
family 1 0 0 0
MIG6 family
family 1 0 1 0
MTAP subfamily
subfamily 1 1 1 1
MINA53 subfamily
subfamily 1 0 1 1
msl-1 family
family 1 0 1 0
MON2 family
family 1 0 0 0
MESH1 family
family 1 0 1 1
MND1 family
family 1 0 0 0
mitochondrion-specific ribosomal protein mS31 family
family 1 0 0 0
MICU3 subfamily
subfamily 1 0 0 0
MCMBP family
family 1 0 1 0
MPDU1 (TC 2.A.43.3) family
family 1 0 0 0
MYZAP family
family 1 0 1 0
myo-inositol 1-phosphate synthase family
family 1 0 0 0
MCTS1 family
family 1 0 1 0
Mediator complex subunit 22 family
family 1 0 0 0
MTURN family
family 1 0 0 0
MAD2 family
family 1 0 1 1
methylmalonyl-CoA mutase family
family 1 0 1 1
misato family
family 1 0 0 0
myelin basic protein family
family 1 0 1 0
MESD family
family 1 0 0 0
MEI4L family
family 1 0 0 0
MAJIN family
family 1 0 0 0
MYDGF family
family 1 0 0 0
Metazoan subfamily
subfamily 1 0 1 0
mask family
family 1 0 0 0
mitochondrion-specific ribosomal protein mS35 family
family 1 0 0 0
MDH type 1 family
family 1 1 1 0
MAF1 family
family 1 0 1 0
MINPP1 subfamily
subfamily 1 0 0 0
mitochondrion-specific ribosomal protein mL64 family
family 1 0 1 0
Metazoan Mic25 subfamily
subfamily 1 0 0 0
MDM1 family
family 1 0 0 0
MICU1 subfamily
subfamily 1 0 1 1
mitochondrion-specific ribosomal protein mS39 family
family 1 0 0 0
MOCS2A subfamily
subfamily 1 0 1 0
Mediator complex subunit 23 family
family 1 1 0 0
Mediator complex subunit 20 family
family 1 0 0 0
MnmA/TRMU family
family 1 0 0 0
mRNA cap 0 methyltransferase family
family 1 0 1 1
MAP65/ASE1 family
family 1 0 1 1
mitochondrion-specific ribosomal protein mS26 family
family 1 0 0 0
MGR2 family
family 1 0 0 0
mis12 family
family 1 0 1 0
MAD1 family
family 1 0 1 0
mitochondrion-specific ribosomal protein mL63 family
family 1 0 1 0
Mediator complex subunit 30 family
family 1 0 0 0
Mediator complex subunit 8 family
family 1 0 0 0
Mediator complex subunit 14 family
family 1 0 0 0
membrane magnesium transporter (TC 1.A.67) family
family 1 0 0 0
MPP6 family
family 1 0 0 0
Mitochondrial peptide exporter (TC 3.A.1.212) subfamily
subfamily 1 0 1 1
mitochondrion-specific ribosomal protein mL52 family
family 1 0 1 0
Mediator complex subunit 27 family
family 1 0 0 0
Metazoan Mic19 subfamily
subfamily 1 0 0 0
MPPE1 family
family 1 0 0 0
Mediator complex subunit 19 family
family 1 0 0 0
MICOS complex subunit Mic60 family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL51 family
family 1 0 1 0
MOS2 family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL48 family
family 1 0 1 1
mitochondrion-specific ribosomal protein mL37 family
family 1 0 1 0
Mediator complex subunit 1 family
family 1 0 1 0
MEMO1 family
family 1 0 1 1
monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL43 family
family 1 0 1 0
Mitochondrion-specific ribosomal protein mL44 subfamily
subfamily 1 0 1 0
MICU2 subfamily
subfamily 1 0 0 0
Mediator complex subunit 9 family
family 1 0 0 0
mitochondrion-specific ribosomal protein mS33 family
family 1 0 0 0
mitochondrion-specific ribosomal protein mS34 family
family 1 0 0 0
MenG/UbiE family
family 1 0 0 0
MMACHC family
family 1 0 1 1
MAK16 family
family 1 0 0 0
Mitochondrion-specific ribosomal protein mS40 subfamily
subfamily 1 0 0 0
mitochondrion-specific ribosomal protein mS37 family
family 1 0 0 0
mitochondrion-specific ribosomal protein mL39 family
family 1 0 1 1
mitochondrion-specific ribosomal protein mS38 family
family 1 1 0 0
Mediator complex subunit 17 family
family 1 0 0 0
MSH3 subfamily
subfamily 1 0 1 1
MoaD family
family 1 0 1 0
methylenetetrahydrofolate reductase family
family 1 0 1 1