Protein Family Synopsis
Family Overview
Special Analysis

TKL Ser/Thr protein kinase family - Overview - Protein Family Synopsis

THE COMPLEX OF WILD-TYPE B-RAF WITH PYRAZOLO PYRIMIDINE INHIBITOR (PDB: 3II5)

Members
(human, all organisms)
34, 192
Drug targets
(human, all organisms)
2, 2
Members with known 3D structures
(human, all organisms)
26, 39
Members with tested compounds
(human, all organisms)
29, 32
Members with active compounds (<100nM)
(human, all organisms)
27, 28
Members with mutations reported
(human, all organisms)
34, 34
Additional analysis is available for this family
- 3D structural analysis

Lineage


protein kinase superfamily (486)
+ Unclassified (11)
MLKL
PEAK1
PKDCC
PRAG1
PXK
RNASEL
SCYL1
SCYL2
SCYL3
TBCK
TEX14
ADCK protein kinase family (5)
+ Unclassified (5)
ADCK5
ADCK2
ADCK1
COQ8A
COQ8B
AGC Ser/Thr protein kinase family (58)
+ Unclassified (15)
SGK1
CIT
MAST4
MAST3
ROCK2
LATS1
ROCK1
STK38
MAST2
SGK3
MASTL
SGK2
LATS2
STK38L
MAST1
+ DMPK subfamily (4)
CDC42BPA
CDC42BPB
CDC42BPG
DMPK
+ GPRK subfamily (7)
GRK1
GRK2
GRK3
GRK4
GRK5
GRK6
GRK7
+ PDPK1 subfamily (2)
PDPK1
PDPK2P
+ PKC subfamily (12)
PKN1
PKN2
PKN3
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCH
PRKCI
PRKCQ
PRKCZ
+ RAC subfamily (3)
AKT1
AKT2
AKT3
+ S6 kinase subfamily (8)
RPS6KA1
RPS6KA2
RPS6KA3
RPS6KA4
RPS6KA5
RPS6KA6
RPS6KB1
RPS6KB2
+ cAMP subfamily (5)
PRKACA
PRKACB
PRKACG
PRKX
PRKY
+ cGMP subfamily (2)
PRKG1
PRKG2
Alpha-type protein kinase family (4)
+ Unclassified (1)
EEF2K
+ ALPK subfamily (3)
ALPK1
ALPK2
ALPK3
BUD32 family (1)
+ Unclassified (1)
TP53RK
CAMK Ser/Thr protein kinase family (73)
+ Unclassified (28)
KALRN
TRIO
PSKH1
PHKG2
MAPKAPK2
MYLK
SPEG
MAPKAPK3
PHKG1
MYLK3
OBSCN
TSSK4
MYLK4
MAPKAPK5
NIM1K
STK40
CAMKV
TTN
TSSK2
TSSK3
PSKH2
PASK
MKNK1
TSSK6
TSSK1B
MYLK2
MKNK2
SNRK
+ AMPK subfamily (1)
SIK1
+ CHK2 subfamily (1)
CHEK2
+ CaMK subfamily (13)
CAMK1
CAMK1D
CAMK1G
CAMK2A
CAMK2B
CAMK2D
CAMK2G
CAMK4
DCLK1
DCLK2
DCLK3
PNCK
STK33
+ DAP kinase subfamily (5)
DAPK1
DAPK2
DAPK3
STK17A
STK17B
+ LKB1 subfamily (1)
STK11
+ NIM1 subfamily (1)
CHEK1
+ PIM subfamily (3)
PIM1
PIM2
PIM3
+ PKD subfamily (3)
PRKD1
PRKD2
PRKD3
+ SNF1 subfamily (14)
BRSK1
BRSK2
HUNK
MARK1
MARK2
MARK3
MARK4
MELK
NUAK1
NUAK2
PRKAA1
PRKAA2
SIK2
SIK3
+ Tribbles subfamily (3)
TRIB1
TRIB2
TRIB3
CK1 Ser/Thr protein kinase family (12)
+ Unclassified (2)
TTBK1
TTBK2
+ Casein kinase I subfamily (7)
CSNK1A1
CSNK1A1L
CSNK1D
CSNK1E
CSNK1G1
CSNK1G2
CSNK1G3
+ VRK subfamily (3)
VRK1
VRK2
VRK3
CMGC Ser/Thr protein kinase family (62)
+ Unclassified (4)
SRPK2
PRPF4B
SRPK1
SRPK3
+ CDC2/CDKX subfamily (29)
CDK1
CDK10
CDK11A
CDK11B
CDK12
CDK13
CDK14
CDK15
CDK16
CDK17
CDK18
CDK19
CDK2
CDK20
CDK3
CDK4
CDK5
CDK6
CDK7
CDK8
CDK9
CDKL1
CDKL2
CDKL3
CDKL4
CDKL5
ICK
MAK
MOK
+ GSK-3 subfamily (2)
GSK3A
GSK3B
+ HIPK subfamily (4)
HIPK1
HIPK2
HIPK3
HIPK4
+ Lammer subfamily (4)
CLK1
CLK2
CLK3
CLK4
+ MAP kinase subfamily (14)
MAPK1
MAPK10
MAPK11
MAPK12
MAPK13
MAPK14
MAPK15
MAPK3
MAPK4
MAPK6
MAPK7
MAPK8
MAPK9
NLK
+ MNB/DYRK subfamily (5)
DYRK1A
DYRK1B
DYRK2
DYRK3
DYRK4
NEK Ser/Thr protein kinase family (11)
+ NIMA subfamily (11)
NEK1
NEK10
NEK11
NEK2
NEK3
NEK4
NEK5
NEK6
NEK7
NEK8
NEK9
PAN3 family (1)
+ Unclassified (1)
PAN3
RIO-type Ser/Thr kinase family (3)
+ Unclassified (3)
RIOK3
RIOK1
RIOK2
STE Ser/Thr protein kinase family (54)
+ MAP kinase kinase kinase subfamily (17)
MAP3K1
MAP3K10
MAP3K11
MAP3K12
MAP3K13
MAP3K14
MAP3K15
MAP3K2
MAP3K20
MAP3K21
MAP3K3
MAP3K4
MAP3K5
MAP3K6
MAP3K7
MAP3K8
MAP3K9
+ MAP kinase kinase subfamily (8)
MAP2K1
MAP2K2
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP2K7
PBK
+ STE20 subfamily (29)
MAP3K19
MAP4K1
MAP4K2
MAP4K3
MAP4K4
MAP4K5
MINK1
NRK
OXSR1
PAK1
PAK2
PAK3
PAK4
PAK5
PAK6
SLK
STK10
STK24
STK25
STK26
STK3
STK39
STK4
STRADA
STRADB
TAOK1
TAOK2
TAOK3
TNIK
Ser/Thr protein kinase family (67)
+ Unclassified (27)
GAK
ERN1
STK16
MOS
TTK
AAK1
SBK1
DSTYK
ERN2
TLK2
STK32C
PDIK1L
CAMKK1
UHMK1
STK35
STK32A
SGK494
CAMKK2
PIK3R4
PINK1
STK31
STK36
NRBP2
BMP2K
STK32B
NRBP1
TLK1
+ APG1/unc-51/ULK1 subfamily (4)
ULK1
ULK2
ULK3
ULK4
+ Aurora subfamily (3)
AURKA
AURKB
AURKC
+ BUB1 subfamily (2)
BUB1
BUB1B
+ CDC5/Polo subfamily (5)
PLK1
PLK2
PLK3
PLK4
PLK5
+ CDC7 subfamily (1)
CDC7
+ CK2 subfamily (3)
CSNK2A1
CSNK2A2
CSNK2A3
+ GCN2 subfamily (4)
EIF2AK1
EIF2AK2
EIF2AK3
EIF2AK4
+ Haspin subfamily (1)
HASPIN
+ I-kappa-B kinase subfamily (4)
CHUK
IKBKB
IKBKE
TBK1
+ S6 kinase subfamily (2)
RPS6KC1
RPS6KL1
+ STKL subfamily (4)
POMK
SBK2
SBK3
STKLD1
+ WEE1 subfamily (3)
PKMYT1
WEE1
WEE2
+ WNK subfamily (4)
WNK1
WNK2
WNK3
WNK4
TKL Ser/Thr protein kinase family (34) *
+ Unclassified (13)
RIPK2
LIMK1
LIMK2
RIPK4
ILK
RIPK1
TESK1
LRRK2
KSR2
KSR1
ANKK1
TESK2
RIPK3
+ MAP kinase kinase kinase subfamily (1)
TNNI3K
+ Pelle subfamily (4)
IRAK1
IRAK2
IRAK3
IRAK4
+ RAF subfamily (3)
ARAF
BRAF
RAF1
+ ROCO subfamily (1)
LRRK1
+ TGFB receptor subfamily (12)
ACVR1
ACVR1B
ACVR1C
ACVR2A
ACVR2B
ACVRL1
AMHR2
BMPR1A
BMPR1B
BMPR2
TGFBR1
TGFBR2
Tyr protein kinase family (90)
+ Unclassified (11)
MUSK
RET
MET
RYK
MST1R
TNK2
TNK1
STYK1
AATK
LMTK2
LMTK3
+ ABL subfamily (2)
ABL1
ABL2
+ AXL/UFO subfamily (3)
AXL
MERTK
TYRO3
+ BRK/PTK6/SIK subfamily (1)
PTK6
+ CSF-1/PDGF receptor subfamily (8)
CSF1R
FLT1
FLT3
FLT4
KDR
KIT
PDGFRA
PDGFRB
+ CSK subfamily (2)
CSK
MATK
+ EGF receptor subfamily (4)
EGFR
ERBB2
ERBB3
ERBB4
+ Ephrin receptor subfamily (14)
EPHA1
EPHA10
EPHA2
EPHA3
EPHA4
EPHA5
EPHA6
EPHA7
EPHA8
EPHB1
EPHB2
EPHB3
EPHB4
EPHB6
+ FAK subfamily (2)
PTK2
PTK2B
+ Fes/fps subfamily (2)
FER
FES
+ Fibroblast growth factor receptor subfamily (4)
FGFR1
FGFR2
FGFR3
FGFR4
+ Insulin receptor subfamily (12)
ALK
DDR1
DDR2
IGF1R
INSR
INSRR
LTK
NTRK1
NTRK2
NTRK3
PTK7
ROS1
+ JAK subfamily (4)
JAK1
JAK2
JAK3
TYK2
+ ROR subfamily (2)
ROR1
ROR2
+ SRC subfamily (10)
BLK
FGR
FRK
FYN
HCK
LCK
LYN
SRC
SRMS
YES1
+ SYK/ZAP-70 subfamily (2)
SYK
ZAP70
+ TEC subfamily (5)
BMX
BTK
ITK
TEC
TXK
+ Tie subfamily (2)
TEK
TIE1